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Table of Contents
Preface
I Defining the Disease
1.1 historical aspects
1.2 definitions and classification
1.3 Epidemiology
1.4 Histopathology including electron microscopy
1.5 Clinical aspects Including natural history according to subsets
Short introduction
1.5.1 vitiligo including acrofacial, universalis
1.5.2 segmental vitiligo Including clinical aspects
1.5.3 Mixed vitiligo
1.5.4 rare variants including inflammatory
1.5.5 subtypes of mucocutaneous pigment cell involvement: mucosal, hair follicle (leukotrichia), nevus cells (halo nevus)
1.5.6 extracutaneous melanocytes
1.5.7 Environmental triggers: Koebner phenomenon and occupational vitiligo
1.5.8 associated disorders and comorbidities includingautoimmune/inflammatory disorders, immunodeficiences, rare monogenic diseases
1.5.9 age and vitiligo: childhood, pregnancy, late-onset
1.5.10 vitiligo and skin of colour
1.6 assessment and scoring including QoL
1.7 Editors synthesis
II Understanding the Disease
2.1 pathophysiology overview
Unifying concepts V-SV
2.2 methods to study vitiligo
2.2.1 in vivo confocal microscopy and other noninvasive techniques
2.2.2 animal models
2.2.3 in vitro
2.3 critical assessment of published data on vitiligo Short introduction
2.3.1 Genetics
2.3.2 epigenetics
2.3.3 melanocyte stability
2.3.4 oxidative stress and intrinsic melanocyte defects
2.3.5 immunity (innate, adaptive). Innate and adaptive separated
2.3.6 peptides, growth factors including POMC and family
2.3.7 Stem cells
2.3.8 other defects and mechanisms
2.4 pathophysiology of segmental vitiligo
2.5 Editors synthesis
III Treating the Disease
3.1 management overview
What has changed in a therapeutic perspective
3.2 discussion of available and new therapies
3.2.1 medical therapies
3.2.2 phototherapies
3.2.3 surgical therapies
3.2.4 depigmenting therapies
3.3combined/sequential/integrated therapies includin g maintenance therapy
3.4 camouflage
3.5 photoprotection
3.6 age, gender, ethnic skin, specific locations
3.7 psychological intervention
3.8 patients perspectives
3.9 discussion of empirical, traditional, alternative approaches
3.10 evidence-based medicine perspective and guidelines
3.11 beyond guidelines
3.12 editors synthesis and perspectives
Subject Index.
I Defining the Disease
1.1 historical aspects
1.2 definitions and classification
1.3 Epidemiology
1.4 Histopathology including electron microscopy
1.5 Clinical aspects Including natural history according to subsets
Short introduction
1.5.1 vitiligo including acrofacial, universalis
1.5.2 segmental vitiligo Including clinical aspects
1.5.3 Mixed vitiligo
1.5.4 rare variants including inflammatory
1.5.5 subtypes of mucocutaneous pigment cell involvement: mucosal, hair follicle (leukotrichia), nevus cells (halo nevus)
1.5.6 extracutaneous melanocytes
1.5.7 Environmental triggers: Koebner phenomenon and occupational vitiligo
1.5.8 associated disorders and comorbidities includingautoimmune/inflammatory disorders, immunodeficiences, rare monogenic diseases
1.5.9 age and vitiligo: childhood, pregnancy, late-onset
1.5.10 vitiligo and skin of colour
1.6 assessment and scoring including QoL
1.7 Editors synthesis
II Understanding the Disease
2.1 pathophysiology overview
Unifying concepts V-SV
2.2 methods to study vitiligo
2.2.1 in vivo confocal microscopy and other noninvasive techniques
2.2.2 animal models
2.2.3 in vitro
2.3 critical assessment of published data on vitiligo Short introduction
2.3.1 Genetics
2.3.2 epigenetics
2.3.3 melanocyte stability
2.3.4 oxidative stress and intrinsic melanocyte defects
2.3.5 immunity (innate, adaptive). Innate and adaptive separated
2.3.6 peptides, growth factors including POMC and family
2.3.7 Stem cells
2.3.8 other defects and mechanisms
2.4 pathophysiology of segmental vitiligo
2.5 Editors synthesis
III Treating the Disease
3.1 management overview
What has changed in a therapeutic perspective
3.2 discussion of available and new therapies
3.2.1 medical therapies
3.2.2 phototherapies
3.2.3 surgical therapies
3.2.4 depigmenting therapies
3.3combined/sequential/integrated therapies includin g maintenance therapy
3.4 camouflage
3.5 photoprotection
3.6 age, gender, ethnic skin, specific locations
3.7 psychological intervention
3.8 patients perspectives
3.9 discussion of empirical, traditional, alternative approaches
3.10 evidence-based medicine perspective and guidelines
3.11 beyond guidelines
3.12 editors synthesis and perspectives
Subject Index.