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000913198 019__ $$a1117301289$$a1117706420
000913198 020__ $$a9783030245917
000913198 020__ $$a3030245918
000913198 0247_ $$a10.1007/978-3-030-24
000913198 035__ $$aSP(OCoLC)on1111952004
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000913198 24500 $$aStructure and function of GPCRs /$$cGuillaume Lebon, editor ; with contributions by F. Acher [and 33 others].
000913198 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000913198 300__ $$a1 online resource (299 pages).
000913198 336__ $$atext$$btxt$$2rdacontent
000913198 337__ $$acomputer$$bc$$2rdamedia
000913198 338__ $$aonline resource$$bcr$$2rdacarrier
000913198 4901_ $$aTopics in medicinal chemistry,$$x1862-247X ;$$v30
000913198 5050_ $$aStructures of Non-rhodopsin GPCRs Elucidated Through X-Ray Crystallography -- NMR Spectroscopy for the Characterization of GPCR Energy Landscapes -- Structure and Activation Mechanism of GPCRs -- Structure-Based Discovery of GPCR Ligands from Crystal Structures and Homology Models -- Integration on Ligand and Structure Based Approaches in GPCRs -- Biased Agonist Pharmacochaperones: Small Molecules in the Toolbox for Selectively Modulating GPCR Activity -- Endosomal PTH Receptor Signaling Through cAMP and Its Consequence for Human Medicine -- Structure and Function Studies of GPCRs by Site-Specific Incorporation of Unnatural Amino Acids -- Fluorescent-Based Strategies to Investigate G Protein-Coupled Receptors: Evolution of the Techniques to a Better Understanding -- Modulation of Metabotropic Glutamate Receptors by Orthosteric, Allosteric, and Light-Operated Ligands.
000913198 506__ $$aAccess limited to authorized users.
000913198 520__ $$aThis book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.
000913198 588__ $$aDescription based on print version record.
000913198 650_0 $$aG proteins$$xReceptors.
000913198 650_0 $$aPharmaceutical technology.
000913198 7001_ $$aLebon, Guillaume,$$eeditor.
000913198 7001_ $$aAcher, F.,$$eauthor.
000913198 77608 $$iPrint version:$$aLebon, Guillaume$$tStructure and Function of GPCRs$$dCham : Springer,c2019$$z9783030245894
000913198 830_0 $$aTopics in medicinal chemistry (Springer (Firm)) ;$$vv. 30.
000913198 852__ $$bebk
000913198 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-24591-7$$zOnline Access$$91397441.1
000913198 909CO $$ooai:library.usi.edu:913198$$pGLOBAL_SET
000913198 980__ $$aEBOOK
000913198 980__ $$aBIB
000913198 982__ $$aEbook
000913198 983__ $$aOnline
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