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Table of Contents
Intro
Preface; Contents; About the Editors
Chapter 1: Editorial: African Perspectives and Approaches for African Healthcare Challenges
1.1 Introduction
1.2 The Virtual Absence of African Perspectives and Approaches
1.3 Significance of a Local Perspective and Approach
1.4 Contents and Potential Value of an African Perspective and/or Approach
1.5 Conclusion: Overview of Book Sections; References
Part I: Emerging Deadly Pathogens and Clinical Practice
Chapter 2: How and Why the Global Emerging Pathogens Treatment Consortium Was Created
2.1 Introduction
2.2 Global Emerging Pathogens Treatment (GET) Consortium
2.2.1 Governance of the GET Consortium
2.3 Conclusion
References
Chapter 3: Emerging Infectious Diseases: A Historical and Scientific Review
3.1 Overview and History
3.2 Stages in the Emergence of an Infectious Disease
3.3 Reported EID Outbreaks
3.4 Animal Diseases of Economic and/or Zoonotic Impact
3.4.1 One Health Program, South Africa
3.4.2 Rinderpest
3.4.3 Rift Valley Fever
3.4.4 Peste de Petits Ruminants (PPR)
3.5 Control of EIDs and Deadly Outbreaks in Humans
3.5.1 Surveillance
3.5.2 Response Mechanism
3.5.3 Research and Training
3.5.4 Public Health Control Measures
3.6 Conclusion
References
Chapter 4: Epidemiology and Management of Lassa Fever in the West African Sub-Region: Overcoming the Socio-cultural Challenges
4.1 Case Vignette
4.2 Introduction
4.3 Epidemiology
4.3.1 Factors That Promote the Epidemics
4.4 Virology
4.5 Pathogenesis
4.6 Clinical Presentation
4.6.1 The Case Definition for Suspected Lassa Fever
4.6.2 Socio-cultural Challenges in Clinical Diagnosis and Management of Lassa Fever
4.7 Laboratory Diagnosis
4.7.1 Logistic Challenges in Laboratory Diagnosis of Lassa Virus Infection
4.8 Treatment
4.9 Prognosis
4.10 Prevention and Control
References; Part II: Social Determinants of EID
Chapter 5: Socio-cultural and Economic Concerns on Use of Convalescent Blood or Plasma for the Management of Ebola Virus Disease in Africa
5.1 Introduction
5.2 Discussion
5.2.1 Use (Standard or Experimental) of Blood as a Form of Therapy in Africa
5.2.2 Feasibility of Using Plasma Component Therapy in Africa
5.2.3 Historical Cases of Use of Plasma in Ebola or Other Viral Hemorrhagic Fever Outbreaks in Africa
5.2.4 Socio-Cultural, Determinants of EVD and Implications for Behavior and Disease Control in Epidemic Situations
5.2.5 Socio-Cultural Challenges in Managing Outbreaks of Emerging Infectious Disease in African Countries
5.2.6 Cultural Concepts and Perceptions of Blood and Blood Donation in Africa: Implications for Blood-Based Therapy in Epidemic Situations
5.2.7 Socio-Cultural Issues in CP Trials for EVD
5.3 Conclusion; References
Chapter 6: The Impact of Ebola Virus Disease on Government Expenditure in Sierra Leone
6.1 Introduction
Preface; Contents; About the Editors
Chapter 1: Editorial: African Perspectives and Approaches for African Healthcare Challenges
1.1 Introduction
1.2 The Virtual Absence of African Perspectives and Approaches
1.3 Significance of a Local Perspective and Approach
1.4 Contents and Potential Value of an African Perspective and/or Approach
1.5 Conclusion: Overview of Book Sections; References
Part I: Emerging Deadly Pathogens and Clinical Practice
Chapter 2: How and Why the Global Emerging Pathogens Treatment Consortium Was Created
2.1 Introduction
2.2 Global Emerging Pathogens Treatment (GET) Consortium
2.2.1 Governance of the GET Consortium
2.3 Conclusion
References
Chapter 3: Emerging Infectious Diseases: A Historical and Scientific Review
3.1 Overview and History
3.2 Stages in the Emergence of an Infectious Disease
3.3 Reported EID Outbreaks
3.4 Animal Diseases of Economic and/or Zoonotic Impact
3.4.1 One Health Program, South Africa
3.4.2 Rinderpest
3.4.3 Rift Valley Fever
3.4.4 Peste de Petits Ruminants (PPR)
3.5 Control of EIDs and Deadly Outbreaks in Humans
3.5.1 Surveillance
3.5.2 Response Mechanism
3.5.3 Research and Training
3.5.4 Public Health Control Measures
3.6 Conclusion
References
Chapter 4: Epidemiology and Management of Lassa Fever in the West African Sub-Region: Overcoming the Socio-cultural Challenges
4.1 Case Vignette
4.2 Introduction
4.3 Epidemiology
4.3.1 Factors That Promote the Epidemics
4.4 Virology
4.5 Pathogenesis
4.6 Clinical Presentation
4.6.1 The Case Definition for Suspected Lassa Fever
4.6.2 Socio-cultural Challenges in Clinical Diagnosis and Management of Lassa Fever
4.7 Laboratory Diagnosis
4.7.1 Logistic Challenges in Laboratory Diagnosis of Lassa Virus Infection
4.8 Treatment
4.9 Prognosis
4.10 Prevention and Control
References; Part II: Social Determinants of EID
Chapter 5: Socio-cultural and Economic Concerns on Use of Convalescent Blood or Plasma for the Management of Ebola Virus Disease in Africa
5.1 Introduction
5.2 Discussion
5.2.1 Use (Standard or Experimental) of Blood as a Form of Therapy in Africa
5.2.2 Feasibility of Using Plasma Component Therapy in Africa
5.2.3 Historical Cases of Use of Plasma in Ebola or Other Viral Hemorrhagic Fever Outbreaks in Africa
5.2.4 Socio-Cultural, Determinants of EVD and Implications for Behavior and Disease Control in Epidemic Situations
5.2.5 Socio-Cultural Challenges in Managing Outbreaks of Emerging Infectious Disease in African Countries
5.2.6 Cultural Concepts and Perceptions of Blood and Blood Donation in Africa: Implications for Blood-Based Therapy in Epidemic Situations
5.2.7 Socio-Cultural Issues in CP Trials for EVD
5.3 Conclusion; References
Chapter 6: The Impact of Ebola Virus Disease on Government Expenditure in Sierra Leone
6.1 Introduction