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Intro; Preface; Contents; Editors and Contributors; Part I: General Implications of Oxidative Stress on Lungs; 1: Nutrition in Inflammatory Lung Diseases; 1.1 Introduction; 1.2 Oxidative Stress; 1.2.1 Free Radicals; 1.2.2 Oxygen Reactive Species; 1.2.3 Oxidative Stress; 1.2.3.1 Implications of Oxidative Stress in the Organism; 1.2.3.2 Oxidative Damage in Lung; 1.3 Inflammation in Lung Diseases; 1.3.1 Inflammatory Cellular Response; 1.3.2 Biological Barriers in Lung; 1.3.3 Acute and Chronic Lung Inflammation; 1.4 Interaction of Nutrients with Inflammatory Elements
1.5 Role of the Diet in Lung Diseases1.5.1 Mediterranean Diet; 1.5.2 Western Diet; 1.5.3 Fruit and Vegetable Consumption; 1.6 Conclusion; References; 2: Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut; 2.1 Introduction; 2.2 Exogenous and Endogenous Oxidation; 2.3 Regeneration of Lung Cells; 2.4 Oxidative Stress in the Lungs; 2.5 Oxidative Stress Markers; 2.6 Antioxidant Defense System; 2.7 Lung Pathology and Oxidative Stress; 2.7.1 COPD; 2.7.2 Bronchial Asthma; 2.7.3 Idiopathic Pulmonary Fibrosis; 2.7.4 Lung Cancer
2.8 Lung Disease Statistics2.9 Molecular Mechanism of Lung Diseases; 2.10 Impact of Smoking on Lung Diseases; 2.11 Lung Disease and Gut Ecosystem; 2.12 Rational Basis for a Systemic Antioxidant and Parenteral/Transmucosal Oxygen-Ozone Tentative Interventional Trial: The Cell-Energy Modulation Biotech, CMB® Protocol; 2.13 Using Natural Antioxidants and Nutrigenomic Cytoprotective Agents to Prevent Oxidative Stress Damage in Lung Caused by Cigarette Smoking; 2.14 Conclusion and Future Direction; References; 3: Oxidative Stress in Neonatal Lung Diseases; 3.1 Introduction
3.2 Perinatal Transition3.3 Vasoactive Molecules Are Involved in the Perinatal Transition; 3.3.1 Nitric Oxide (NO); 3.3.2 Prostacyclin (PGI2); 3.3.3 Thromboxane A2 (TXA2); 3.3.4 Endothelin; 3.4 Free Radical Generating Systems; 3.4.1 Mitochondrial Electron Transport Chain; 3.4.2 NADPH Oxidase (NOX); 3.4.3 eNOS Uncoupling; 3.5 Free Radicals in Neonates; 3.6 Antioxidant System; 3.6.1 General Aspects; 3.6.2 Caffeine; 3.6.3 Melatonin; 3.6.4 Taurine; 3.7 Neonatal Lung Diseases; 3.7.1 General Aspects; 3.7.2 Respiratory Distress Syndrome (RDS) and Bronchopulmonary Dysplasia (BPD)
3.7.3 Persistent Pulmonary Hypertension of the Newborn (PPHN)3.8 Conclusion; References; 4: DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases; 4.1 Introduction; 4.2 DNA Repair Protein OGG1 Response to Lung Infection; 4.2.1 OGG1 Plays a Role in Bacterial Infection; 4.2.1.1 Pseudomonas aeruginosa; 4.2.1.2 Klebsiella pneumoniae; 4.2.1.3 Other Bacteria; 4.2.2 OGG1 Affects Viral Infection; 4.2.3 OGG1 Affects Fungus Infection; 4.3 OGG1 Is Linked to Inflammatory Lung Diseases; 4.3.1 OGG1 Responses in Pulmonary Hyperoxia; 4.3.2 OGG1 Mediates Pulmonary Fibrosis
1.5 Role of the Diet in Lung Diseases1.5.1 Mediterranean Diet; 1.5.2 Western Diet; 1.5.3 Fruit and Vegetable Consumption; 1.6 Conclusion; References; 2: Oxidative Stress and Smoke-Related Lung Diseases: A Tentative Approach Through the Blood, Lungs, and Gut; 2.1 Introduction; 2.2 Exogenous and Endogenous Oxidation; 2.3 Regeneration of Lung Cells; 2.4 Oxidative Stress in the Lungs; 2.5 Oxidative Stress Markers; 2.6 Antioxidant Defense System; 2.7 Lung Pathology and Oxidative Stress; 2.7.1 COPD; 2.7.2 Bronchial Asthma; 2.7.3 Idiopathic Pulmonary Fibrosis; 2.7.4 Lung Cancer
2.8 Lung Disease Statistics2.9 Molecular Mechanism of Lung Diseases; 2.10 Impact of Smoking on Lung Diseases; 2.11 Lung Disease and Gut Ecosystem; 2.12 Rational Basis for a Systemic Antioxidant and Parenteral/Transmucosal Oxygen-Ozone Tentative Interventional Trial: The Cell-Energy Modulation Biotech, CMB® Protocol; 2.13 Using Natural Antioxidants and Nutrigenomic Cytoprotective Agents to Prevent Oxidative Stress Damage in Lung Caused by Cigarette Smoking; 2.14 Conclusion and Future Direction; References; 3: Oxidative Stress in Neonatal Lung Diseases; 3.1 Introduction
3.2 Perinatal Transition3.3 Vasoactive Molecules Are Involved in the Perinatal Transition; 3.3.1 Nitric Oxide (NO); 3.3.2 Prostacyclin (PGI2); 3.3.3 Thromboxane A2 (TXA2); 3.3.4 Endothelin; 3.4 Free Radical Generating Systems; 3.4.1 Mitochondrial Electron Transport Chain; 3.4.2 NADPH Oxidase (NOX); 3.4.3 eNOS Uncoupling; 3.5 Free Radicals in Neonates; 3.6 Antioxidant System; 3.6.1 General Aspects; 3.6.2 Caffeine; 3.6.3 Melatonin; 3.6.4 Taurine; 3.7 Neonatal Lung Diseases; 3.7.1 General Aspects; 3.7.2 Respiratory Distress Syndrome (RDS) and Bronchopulmonary Dysplasia (BPD)
3.7.3 Persistent Pulmonary Hypertension of the Newborn (PPHN)3.8 Conclusion; References; 4: DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases; 4.1 Introduction; 4.2 DNA Repair Protein OGG1 Response to Lung Infection; 4.2.1 OGG1 Plays a Role in Bacterial Infection; 4.2.1.1 Pseudomonas aeruginosa; 4.2.1.2 Klebsiella pneumoniae; 4.2.1.3 Other Bacteria; 4.2.2 OGG1 Affects Viral Infection; 4.2.3 OGG1 Affects Fungus Infection; 4.3 OGG1 Is Linked to Inflammatory Lung Diseases; 4.3.1 OGG1 Responses in Pulmonary Hyperoxia; 4.3.2 OGG1 Mediates Pulmonary Fibrosis