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000913785 019__ $$a1117633141
000913785 020__ $$a9789813292673$$q(electronic book)
000913785 020__ $$a9813292679$$q(electronic book)
000913785 020__ $$z9789813292666
000913785 0247_ $$a10.1007/978-981-32-9267-3$$2doi
000913785 035__ $$aSP(OCoLC)on1119722184
000913785 035__ $$aSP(OCoLC)1119722184$$z(OCoLC)1117633141
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000913785 050_4 $$aQH467$$b.G56 2019eb
000913785 08204 $$a572.8/6459$$223
000913785 1001_ $$aGhosh, Shrestha,$$eauthor.
000913785 24510 $$aSIRT6 activities in DNA damage repair and premature aging :$$bfunctions of SIRT6 /$$cShrestha Ghosh.
000913785 264_1 $$aSingapore :$$bSpringer,$$c[2019]
000913785 264_4 $$c©2019
000913785 300__ $$a1 online resource.
000913785 336__ $$atext$$btxt$$2rdacontent
000913785 337__ $$acomputer$$bc$$2rdamedia
000913785 338__ $$aonline resource$$bcr$$2rdacarrier
000913785 4901_ $$aSpringer theses,$$x2190-5053
000913785 500__ $$a"Doctoral thesis accepted by The University of Hong Kong, Hong Kong, China."
000913785 504__ $$aIncludes bibliographical references.
000913785 5050_ $$aIntro; Supervisor's Foreword; Abstract; Preface; Acknowledgements; Contents; List of Contributors; Acronyms and Abbreviations; List of Figures; List of Tables; 1 Introduction; 1.1 Premature Aging and Genomic Instability; 1.1.1 Chronological Aging and Premature Aging; 1.1.2 A Brief Background of Progeroid Syndromes; 1.1.3 Genomic Instability and Premature Aging; 1.2 Lamins and Laminopathies; 1.2.1 The Nuclear Lamins; 1.2.2 A Brief Outlook of Laminopathies; 1.2.3 Hutchinson-Gilford Progeria Syndrome (HGPS); 1.2.4 Atypical HGPS Conditions; 1.3 Role of Sirtuins in Premature Aging
000913785 5058_ $$a1.3.1 Sirtuins … At a Glance1.3.2 Sirt1; 1.3.3 Sirt2; 1.3.4 Sirt3; 1.3.5 Sirt4; 1.3.6 Sirt5; 1.3.7 Sirt6; 1.3.8 Sirt7; 1.4 An Overview of SIRT6; 1.4.1 Structure and Localization of SIRT6; 1.4.2 Diverse Functions of SIRT6; 1.4.3 Post-translational Modifications of SIRT6; 1.4.4 Perspectives; 1.5 p53: In a Nutshell; 1.5.1 Domains of p53 and Their Associated Functions; 1.5.2 Mechanisms of p53 Activation and Regulation; 1.5.3 Perspectives; 1.6 Hypotheses and Objectives of Study; 1.6.1 Hypothesis I: A Potential Interlinkage Between Lamins and SIRT6 in DNA Damage Repair and Premature Aging
000913785 5058_ $$a1.6.2 Hypothesis II: A Potential Functional Interlinkage Between SIRT6 and P53 in Accelerated Cellular Senescence and Premature Aging1.6.3 Hypothesis III: Other Post-translational Modifications of SIRT6 with Regulatory Roles in DNA Damage Repair Process; References; 2 Materials and Methods; 2.1 Materials; 2.1.1 Cell Lines; 2.1.2 Mouse Lines; 2.1.3 Constructs; 2.1.4 Antibodies; 2.1.5 Reagents; 2.1.6 Primers; 2.2 Methods; 2.2.1 Cell Culture, Transfections and Treatment with Reagents; 2.2.2 Mouse Embryonic Fibroblast (MEF) Collection; 2.2.3 Genotyping of Tissues from Mice
000913785 5058_ $$a2.2.18 Isolation of Bone Marrow Stromal Cells, and Cells from Thymus and Spleen2.2.19 Immunostaining for Fluorescence-Activated Cell Sorting (FACS) Analysis; 2.2.20 Annexin-V Staining; 2.2.21 Statistical Analysis; References; 3 Results-I. Lamin A is an Endogenous Activator of SIRT6 in DNA Damage Repair Process; 3.1 Introduction; 3.2 Results; 3.2.1 Lamin A is a Direct Interacting Partner of SIRT6; 3.2.2 The Core Domain of SIRT6 Plays a Critical Role in Interacting with Lamin A; 3.2.3 The C-Terminus of Lamin A Dictates Its Binding with SIRT6; 3.2.4 Lamin A Enhances SIRT6 Deacetylase Activity
000913785 506__ $$aAccess limited to authorized users.
000913785 520__ $$aThis book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging. It mainly presents research on the nuclear lamin A, notably the upregulation of p53 and acetylation etc. Taken together, these studies reveal the various regulatory roles of SIRT6, which are of substantial biological relevance in DNA damage repair, aging and longevity, and can have significant implications in devising therapeutic strategies to combat age-associated pathologies. Given its scope, the book offers a valuable resource for students and researchers in the fields of genetics, cell biology, molecular biology etc.
000913785 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 17, 2019).
000913785 650_0 $$aSirtuins.
000913785 650_0 $$aDNA repair.
000913785 650_0 $$aAging$$xGenetic aspects.
000913785 77608 $$iPrint version:$$aGhosh, Shrestha$$tSIRT6 Activities in DNA Damage Repair and Premature Aging : Functions of SIRT6$$dSingapore : Springer,c2019$$z9789813292666
000913785 830_0 $$aSpringer theses.
000913785 852__ $$bebk
000913785 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-32-9267-3$$zOnline Access$$91397441.1
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000913785 980__ $$aEBOOK
000913785 980__ $$aBIB
000913785 982__ $$aEbook
000913785 983__ $$aOnline
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