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000913806 019__ $$a1117462909$$a1117628859$$a1117936685
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000913806 0247_ $$a10.1007/978-981-13-8958-0$$2doi
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000913806 24500 $$aClinical epigenetics /$$cLuke B. Hesson, Antonia L. Pritchard, editors.
000913806 264_1 $$aSingapore :$$bSpringer,$$c[2019]
000913806 264_4 $$c©2019
000913806 300__ $$a1 online resource :$$billustrations
000913806 336__ $$atext$$btxt$$2rdacontent
000913806 337__ $$acomputer$$bc$$2rdamedia
000913806 338__ $$aonline resource$$bcr$$2rdacarrier
000913806 5050_ $$aIntro; Preface; Epigenetics: A Lay Description; Epigenetics: A Scientific Description; Contents; About the Editors; 1: Genetics and Epigenetics: A Historical Overview; 1.1 The Early Origins of Genetics; 1.2 Discovery of DNA; 1.3 Early Characterisation of DNA; 1.4 Discovering That Genes Are Made of DNA; 1.5 The Birth and Evolution of Epigenetics; 1.6 The Double Helix Structure of DNA; 1.7 The Discovery of DNA Methylation; 1.8 The X-Chromosome and Its Unique Place in Genetics and Epigenetics; 1.9 Heritability of DNA Methylation; 1.10 Genomic Imprinting; 1.11 Why Do Genes Become Imprinted?
000913806 5058_ $$a1.12 How Do Genes Become Imprinted?1.13 Histones, Nucleosomes and Chromatin Structure; 1.14 Cancer Epigenetics; 1.15 A Molecular Definition of the Term `Gene;́ 1.16 CpG Islands; 1.17 How Does DNA Methylation Cause Transcriptional Silencing?; 1.18 Epigenomics; 1.19 Key Milestones in Genetics and Epigenetics; 1.20 Key Discoveries; References; 2: The DNA Methylation Machinery; 2.1 DNA Methylation/Methylcytosine; 2.2 Readers of Methylcytosine: DNA Methylation and Gene Expression; 2.2.1 Methyl-CpG-Binding Domain Proteins (MBD); 2.3 Writers of Methylcytosine: DNA Methyltransferases (DNMTs)
000913806 5058_ $$a2.3.1 The Function of DNMTs: Maintenance Methylation2.3.2 The Function of DNMTs: Establishment of DNA Methylation; 2.3.3 CpG Islands; 2.4 Erasers of Methylcytosine; 2.4.1 Regulation of DNA Demethylation by TET Enzymes; 2.5 Conclusion; References; 3: 5-Methylcytosine and Its Oxidized Derivatives; 3.1 Introduction; 3.2 DNA Methyltransferases; 3.3 The Function of 5-Methylcytosine; 3.4 Mutations in DNMT1; 3.5 Mutations in DNMT3A; 3.6 Mutations in DNMT3B; 3.7 5-Methylcytosine-Binding Proteins; 3.8 5-Methylcytosine Oxidases, the TET Proteins
000913806 5058_ $$a3.9 Biological Role of 5-Hydroxymethylcytosine in Development and Disease3.10 Mutations in TET2; 3.11 Proteins That Bind to Oxidized 5-Methylcytosine Derivatives; References; 4: The Role of Nucleosomes in Epigenetic Gene Regulation; 4.1 Introduction; 4.2 The Role of the Nucleosome; 4.2.1 Nucleosome Remodelling; 4.2.2 Variant Nucleosomes; 4.3 Histone Post-Translational Modifications; 4.3.1 Histone Acetylation; 4.3.2 Histone Methylation; 4.4 DNA Methylation; 4.5 Transcription Regulation; 4.5.1 Promoters; 4.5.1.1 Histone Modifications at Promoters; 4.5.1.2 Histone Variants at Promoters
000913806 5058_ $$a4.5.1.3 Nucleosome Positioning at Promoters4.5.1.4 DNA Methylation at Promoters; 4.5.1.5 Promoter Nucleosomes and Cancer; 4.5.2 Enhancers; 4.5.2.1 Histone Modifications at Enhancers; 4.5.2.2 Nucleosome Positioning at Enhancers; 4.5.2.3 DNA Methylation at Enhancers; 4.5.3 Gene Bodies; 4.5.3.1 Histone Modifications at Gene Bodies; 4.5.3.2 Nucleosome Positioning at Gene Bodies; 4.5.3.3 DNA Methylation at Gene Bodies; 4.5.4 Bivalent Chromatin; 4.5.4.1 Bivalent Promoters; 4.5.4.2 Bivalent Enhancers; 4.5.5 Nucleosome Asymmetry; 4.6 Future Directions; 4.7 Concluding Remarks; References
000913806 506__ $$aAccess limited to authorized users.
000913806 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 18, 2019).
000913806 650_0 $$aEpigenetics.
000913806 650_0 $$aMedical genetics.
000913806 7001_ $$aHesson, Luke B.,$$eeditor.
000913806 7001_ $$aPritchard, Antonia L.,$$eeditor.
000913806 77608 $$iPrint version:$$aHesson, Luke B.$$tClinical Epigenetics$$dSingapore : Springer,c2019$$z9789811389573
000913806 852__ $$bebk
000913806 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-13-8958-0$$zOnline Access$$91397441.1
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