Unlimited

Authorized users

Can lend chapters, not whole ebooks

Fc mediated activity of antibodies : structural and functional diversity / Jeffrey V. Ravetch, Falk Nimmerjahn.

9783030310530 (electronic book)
3030310531 (electronic book)

Cham : Springer, 2019.

English

1 online resource (155 pages).

10.1007/978-3-030-31

QR185.8.F33

616.079

This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.

Includes bibliographical references.

Access limited to authorized users.

Online resource; title from PDF title page (SpringerLink, viewed September 20, 2019).

Current topics in microbiology and immunology ; 423.

Online Resources > Ebooks
All Resources