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000914779 019__ $$a1121276378
000914779 020__ $$a9783030187224$$q(electronic book)
000914779 020__ $$a3030187225$$q(electronic book)
000914779 020__ $$z9783030187217
000914779 0247_ $$a10.1007/978-3-030-18722-4$$2doi
000914779 0247_ $$a10.1007/978-3-030-18
000914779 035__ $$aSP(OCoLC)on1120770950
000914779 035__ $$aSP(OCoLC)1120770950$$z(OCoLC)1121276378
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000914779 049__ $$aISEA
000914779 050_4 $$aRC271.C5
000914779 08204 $$a616.994061$$223
000914779 1001_ $$aLink, Wolfgang$$q(Wolfgang Alexander),$$eauthor.
000914779 24510 $$aPrinciples of cancer treatment and anticancer drug development /$$cby Wolfgang Link.
000914779 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000914779 300__ $$a1 online resource (xiv, 145 pages) :$$billustrations.
000914779 336__ $$atext$$btxt$$2rdacontent
000914779 337__ $$acomputer$$bc$$2rdamedia
000914779 338__ $$aonline resource$$bcr$$2rdacarrier
000914779 504__ $$aIncludes bibliographical references and index.
000914779 5050_ $$aPreface -- Acknowledgements -- Contents -- Abbreviations -- Introduction -- Cancer Therapy -- Cancer drug resistance -- Drug Discovery and Development -- Economic and social implications of modern drug discovery. Index.
000914779 506__ $$aAccess limited to authorized users.
000914779 520__ $$aThis book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.
000914779 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed September 24, 2019).
000914779 650_0 $$aCancer$$xChemotherapy.
000914779 650_0 $$aCancer$$xChemoprevention.
000914779 650_0 $$aDrug resistance in cancer cells.
000914779 650_0 $$aCancer$$xTreatment.
000914779 852__ $$bebk
000914779 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-18722-4$$zOnline Access$$91397441.1
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000914779 980__ $$aEBOOK
000914779 980__ $$aBIB
000914779 982__ $$aEbook
000914779 983__ $$aOnline
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