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000917118 019__ $$a1127115565$$a1127946115
000917118 020__ $$a9781493998029$$q(electronic book)
000917118 020__ $$a1493998021$$q(electronic book)
000917118 020__ $$z9781493998012
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000917118 0247_ $$a10.1007/978-1-4939-9802-9$$2doi
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000917118 24500 $$aOmics approaches to understanding muscle biology /$$cJatin George Burniston, Yi-Wen Chen, editors.
000917118 264_1 $$aNew York :$$bSpringer,$$c[2019]
000917118 264_4 $$c©2019
000917118 300__ $$a1 online resource :$$billustrations.
000917118 336__ $$atext$$btxt$$2rdacontent
000917118 337__ $$acomputer$$bc$$2rdamedia
000917118 338__ $$aonline resource$$bcr$$2rdacarrier
000917118 4901_ $$aMethods in physiology
000917118 5050_ $$aPart I: Genomic and Epi-genomic.- 1) GWAS/muscle function and diseases (by Eric Hoffman).- 2) Whole genome and whole exon sequencing/muscle disorders (by Silvère van der Maarel and Richard Lemmers).- 3) Epi-genome approaches/muscle regeneration (by Vittorio Sartorelli).- Part II: Transcriptomic.- 4) RNA profiling (by Yi-Wen Chen, confirmed).- 5) miRNA profiling (by Alyson Fiorillo).- 6) Single cell profiling in muscle (byPier Lorenzo Puri).- 7) Statistics and bioinformatics (by Heather Gordish).- Part III: Proteomic.- 8). Proteome profiling of human/ clinical samples -- i.e. necessarily label-free techniques (by Lawrence Mandarino).- 9) Proteome profiling of cell and animal models -- i.e. label techniques such as SILAC (by Matthias Mann OR SILAM with JR Yates III).- 10) Global analysis of post-translational modifications (by David E James).- 11) Proteome dynamics -- synthesis and degradation on a proteome wide scale (by Jatin Burniston, confirmed).- Part IV: Metabolomic.- 12) Non-targeted metabolomics using mass spectrometry (by Charles Burant).
000917118 506__ $$aAccess limited to authorized users.
000917118 520__ $$aThis book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders. The various sections are categorized according to the level of biological organization, namely, genomics (DNA), transcriptomics (RNA), proteomics (protein), and metabolomics (metabolite). With skeletal muscle as the unifying theme, and featuring contributions from leading experts in this traditional field of research, it highlights the importance of skeletal muscle tissue in human development, health and successful ageing. It also discusses other fascinating topics like developmental biology, muscular dystrophies, exercise, insulin resistance and atrophy due to disuse, ageing or other muscle diseases, conveying the vast opportunities for generating new hypotheses as well as testing existing hypotheses by combining high-throughput techniques with proper experiment designs, bioinformatics and statistical analyses. Presenting the latest research techniques, this book is a valuable resource for the physiology community, particularly researchers and grad students who want to explore the new opportunities for omics technologies in basic physiology research.
000917118 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 14, 2019).
000917118 650_0 $$aMuscles$$xPhysiology.
000917118 650_0 $$aMuscles$$xDiseases.
000917118 650_0 $$aMuscles$$xMolecular aspects.
000917118 650_0 $$aHuman molecular genetics.
000917118 7001_ $$aBurniston, Jatin George,$$eeditor.
000917118 7001_ $$aChen, Yi-Wen,$$eeditor.
000917118 77608 $$iPrint version:$$aBurniston, Jatin George$$tOmics Approaches to Understanding Muscle Biology$$dNew York, NY : Springer,c2019$$z9781493998012
000917118 830_0 $$aMethods in physiology series.
000917118 852__ $$bebk
000917118 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-1-4939-9802-9$$zOnline Access$$91397441.1
000917118 909CO $$ooai:library.usi.edu:917118$$pGLOBAL_SET
000917118 980__ $$aEBOOK
000917118 980__ $$aBIB
000917118 982__ $$aEbook
000917118 983__ $$aOnline
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