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000917123 019__ $$a1127277633
000917123 020__ $$a9783030258900$$q(electronic book)
000917123 020__ $$a3030258904$$q(electronic book)
000917123 020__ $$z9783030258894
000917123 020__ $$z3030258890
000917123 0247_ $$a10.1007/978-3-030-25890-0$$2doi
000917123 035__ $$aSP(OCoLC)on1127579719
000917123 035__ $$aSP(OCoLC)1127579719$$z(OCoLC)1127277633
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000917123 049__ $$aISEA
000917123 050_4 $$aRC931.O73
000917123 08204 $$a616.716$$223
000917123 24500 $$aOsteosarcopenia: bone, muscle and fat interactions /$$cGustavo Duque, editor.
000917123 264_1 $$aCham :$$bSpringer,$$c2019.
000917123 300__ $$a1 online resource (xvi, 383 pages) :$$billustrations.
000917123 336__ $$atext$$btxt$$2rdacontent
000917123 337__ $$acomputer$$bc$$2rdamedia
000917123 338__ $$aonline resource$$bcr$$2rdacarrier
000917123 500__ $$aIncludes index.
000917123 506__ $$aAccess limited to authorized users.
000917123 520__ $$aThis edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions ? including the role of local bone and muscle fat ? followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.
000917123 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed November 11, 2019).
000917123 650_0 $$aOsteoporosis.
000917123 650_0 $$aMusculoskeletal diseases in old age.
000917123 650_0 $$aMuscles$$xDiseases.
000917123 650_0 $$aAging$$xPhysiological aspects.
000917123 7001_ $$aDuque, Gustavo.$$eeditor.
000917123 77608 $$iPrint version: $$z3030258890$$z9783030258894$$w(OCoLC)1105354709
000917123 852__ $$bebk
000917123 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-25890-0$$zOnline Access$$91397441.1
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000917123 980__ $$aEBOOK
000917123 980__ $$aBIB
000917123 982__ $$aEbook
000917123 983__ $$aOnline
000917123 994__ $$a92$$bISE