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000917373 019__ $$a1129964368$$a1130642447
000917373 020__ $$a9783030324599$$q(electronic book)
000917373 020__ $$a3030324591$$q(electronic book)
000917373 020__ $$z9783030324582
000917373 0248_ $$a10.1007/978-3-030-32
000917373 035__ $$aSP(OCoLC)on1129143469
000917373 035__ $$aSP(OCoLC)1129143469$$z(OCoLC)1129964368$$z(OCoLC)1130642447
000917373 040__ $$aLQU$$beng$$erda$$cLQU$$dN$T$$dSCB$$dYDXIT$$dGW5XE
000917373 049__ $$aISEA
000917373 050_4 $$aRC606.6$$b.V36 2019
000917373 08204 $$a616.97/92$$223
000917373 1001_ $$aVan Regenmortel, M. H. V.,$$eauthor.
000917373 24510 $$aHIV/AIDS :$$bimmunochemistry, reductionism and vaccine design : a review of 20 years of research /$$cMarc H V Van Regenmortel.
000917373 264_1 $$aCham, Switzerland :$$bSpringer,$$c[2019]
000917373 300__ $$a1 online resource
000917373 336__ $$atext$$btxt$$2rdacontent
000917373 337__ $$acomputer$$bc$$2rdamedia
000917373 338__ $$aonline resource$$bcr$$2rdacarrier
000917373 504__ $$aIncludes bibliographical references.
000917373 5050_ $$aPart I.Immunochemistry -- 1 What is a B cell epitope -- 2 Molecular design versus empirical discovery in peptide-based vaccines. Coming to terms with fuzzy recognition sites and ill-defined structure-function relationships in immunology -- 3 Synthetic Peptide Vaccines and the Search for Neutralization B Cell Epitopes -- 4 Specificity, polyspecificity, and heterospecificity of antibody-antigen recognition -- Part II. Reductionism -- 5 Reductionism and the search for structure-function relationships in antibody molecules -- 6 Reductionism and complexity in molecular biology -- 7 Editorial: Biological complexity emerges from the ashes of genetic reductionism -- 8 The rational design of biological complexity: A deceptive metaphor., 9 Basic research in HIV vaccinology is hampered by reductionist thinking -- 10 Commentary: Basic Research in HIV Vaccinology Is Hampered by Reductionist Thinking -- 11 Nature and Consequences of Biological Reductionism for the Immunological Study of Infectious Diseases., Part III. Vaccinology -- 12 Limitations to the structure-based design of HIV-1 vaccine immunogens -- 13 Two meanings of reverse vaccinology and the empirical nature of vaccine science -- 14 Requirements for empirical immunogenicity trials, rather than structure-based design, for developing an effective HIV vaccine -- 15 Paradigm Changes and the Future of HIV Vaccine Research: A Summary of a Workshop Held in Baltimore on 20 November 2013 -- 16 Editorial: Paradigm changes are required in HIV vaccine research -- 17 An outdated notion of antibody specificity is one of the major detrimental assumptions of the structure-based reverse vaccinology paradigm, which prevented it from helping to develop an effective HIV-1 vaccine -- 18 More surprises in the development of an HIV vaccine -- 19 Why Does the Molecular Structure of Broadly Neutralizing Monoclonal Antibodies Isolated from Individuals Infected with HIV-1 not Inform the Rational Design of an HIV-1 Vaccine? -- 20 Old a nd New Concepts and Strategies in HIV Vaccinology: A Report from a Workshop held in Rome on 17 June 2016 -- 21 Structure-Based Reverse Vaccinology Failed in the Case of HIV Because it Disregarded Accepted Immunological Theory -- 22 Immune systems rather than antigenic epitopes elicit and produce protective antibodies against HIV -- 23 Development of a Preventive HIV Vaccine Requires Solving Inverse Problems Which Is Unattainable by Rational Vaccine Design -- 24 Viral species, viral genomes and HIV vaccine design: is the rational design of biological complexity a utopia?
000917373 506__ $$aAccess limited to authorized users.
000917373 520__ $$aThis book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades. Accompanied by extensive comments putting the material into an up-to-date context, all three parts of the book offer a broad overview of the numerous unsuccessful attempts made in recent years to develop a preventive HIV vaccine. Providing a detailed review and analysis of studies published from 1998 to the present day, it examines the likely reasons for the failure to develop an HIV vaccine despite multi-million dollar investments.
000917373 588__ $$aDescription based on online resource; title from digital title page (viewed on December 16, 2019).
000917373 650_0 $$aAIDS (Disease)$$xTreatment.
000917373 650_0 $$aAIDS (Disease)$$xResearch.
000917373 650_0 $$aHIV (Viruses)$$xTreatment.
000917373 650_0 $$aHIV (Viruses)$$xResearch.
000917373 650_0 $$aAIDS vaccines.
000917373 650_0 $$aImmunochemistry.
000917373 852__ $$bebk
000917373 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-32459-9$$zOnline Access$$91397441.1
000917373 909CO $$ooai:library.usi.edu:917373$$pGLOBAL_SET
000917373 980__ $$aEBOOK
000917373 980__ $$aBIB
000917373 982__ $$aEbook
000917373 983__ $$aOnline
000917373 994__ $$a92$$bISE