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Current immunotherapeutic strategies in cancer / Matthias Theobald, editor.

9783030237653 (electronic book)
3030237656 (electronic book)
9783030237646

Cham : Springer, [2020]

©2020

English

1 online resource.

10.1007/978-3-030-23765-3 doi

RC271.I45 C87 2020eb

616.99/406

This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient's cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

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Online resource; title from PDF title page (SpringerLink, viewed September 17, 2019).

Recent results in cancer research ; 214.

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