Part I Historical Overview of Cancer and Vitamin C. 1. Introduction to Vitamin C and Cancer Clinical Studies: A Historical Perspective. Part II Mechanims of Action for Vitamin C in Cancer. 2. High-Dose Intravenous Ascorbate as a Pro-Oxidant Inducing Cancer Cell Death. 3. Pharmacological Ascorbate Influences Multiple Cellular Pathways Preferentially in Cancer Cells. 4. Ascorbate and the Hypoxic Response in Cancer. 5. Pharmacological Ascorbate as a Radiosensitizer. 6. Vitamin C and Somatic Cell Reprogramming. Part III Vitamin C and Cancer Clinical Studies. 7. Vitamin C and Cancer: An Overview of Recent Clinical Trials. 8. Orthomolecular Approaches for the Use of Intravenous Vitamin C: Administration by Integrative and Naturopathic Doctors.