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000929824 019__ $$a1144869920$$a1148887393$$a1151194860
000929824 020__ $$a9783030340254$$q(electronic book)
000929824 020__ $$a3030340252$$q(electronic book)
000929824 020__ $$z3030340244
000929824 020__ $$z9783030340247
000929824 0247_ $$a10.1007/978-3-030-34025-4$$2doi
000929824 035__ $$aSP(OCoLC)on1144088189
000929824 035__ $$aSP(OCoLC)1144088189$$z(OCoLC)1144869920$$z(OCoLC)1148887393$$z(OCoLC)1151194860
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000929824 049__ $$aISEA
000929824 050_4 $$aRC268.5
000929824 08204 $$a571.9/78$$223
000929824 24500 $$aTumor microenvironment :$$bthe main driver of metabolic adaptation /$$cJacinta Serpa, editor.
000929824 260__ $$aCham :$$bSpringer,$$c©2020.
000929824 300__ $$a1 online resource
000929824 336__ $$atext$$btxt$$2rdacontent
000929824 337__ $$acomputer$$bc$$2rdamedia
000929824 338__ $$aonline resource$$bcr$$2rdacarrier
000929824 4901_ $$aAdvances in experimental medicine and biology,$$x2214-8019 ;$$vvolume 1219
000929824 504__ $$aIncludes bibliographical references.
000929824 5050_ $$aPreface -- Tumor microenvironment a job of several holders -- Tumor microenvironment- a selective pressure boosting cancer -- Lactate and lactate transporters as key players in the maintenance of the Warburg effect -- Section 1. Adaptive metabolic features are sustained by tumor microenvironment -- Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis -- Gut microbiota and cancer of the host: colliding interests -- Metabolic plasticity of tumor cells: how they do adapt to food deprivation -- Multifaceted oncogenic role of adipocytes in the tumour microenvironment -- Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology -- Monocytes and macrophages in cancer: unsuspected roles -- Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression -- Microenvironment driven metabolic adaptation in melanoma -- Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis -- Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt -- The bone marrow niche -- the tumor microenvironment that ensures leukemia progression -- Section 3. Metabolic fitness and therapy response in cancer -- Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer -- The metabolic remodelling in lung cancer and its putative consequence in therapy response -- Hydrogen sulfide metabolism and signaling in the tumor microenvironment -- Using metabolic adaptation to design new drugs -- Metabolomics- a new way of screening cancer -- NMR as a tool for metabolomics -- Section 5. Animal models- addressing cancer microenvironment -- Animal models to study cancer and its microenvironment -- Modulating the metabolic phenotype of cancer microenvironment -- Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae -- Section 6. In vitro and ex vivo cancer models -- In vitro and ex vivo models- the tumor microenvironment in a flask -- Index.
000929824 506__ $$aAccess limited to authorized users.
000929824 520__ $$aThis book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
000929824 588__ $$aOnline resource; title from PDF title page (SpringerLink, viewed April 1, 2020).
000929824 650_0 $$aTumors$$xMetabolism.
000929824 650_0 $$aCancer cells$$xGrowth.
000929824 650_0 $$aCancer cells$$xAdaptation.
000929824 7001_ $$aSerpa, Jacinta,$$eeditor,$$eauthor.
000929824 77608 $$iPrint version:$$tTumor microenvironment.$$dCham : Springer, ©2020$$z3030340244$$z9783030340247$$w(OCoLC)1121129383
000929824 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1219.
000929824 852__ $$bebk
000929824 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-34025-4$$zOnline Access$$91397441.1
000929824 909CO $$ooai:library.usi.edu:929824$$pGLOBAL_SET
000929824 980__ $$aEBOOK
000929824 980__ $$aBIB
000929824 982__ $$aEbook
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