Tumor microenvironment : the main driver of metabolic adaptation / Jacinta Serpa, editor.
Serpa, Jacinta, editor, author.
2020
RC268.5
Available Online

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Title Tumor microenvironment : the main driver of metabolic adaptation / Jacinta Serpa, editor.
ISBN 9783030340254 (electronic book)
3030340252 (electronic book)
3030340244
9783030340247
DOI https://doi.org/10.1007/978-3-030-34025-4
Publication Details Cham : Springer, ©2020.
Language English
Description 1 online resource
Item Number 10.1007/978-3-030-34025-4 doi
Call Number RC268.5
Dewey Decimal Classification 571.9/78
Summary This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed April 1, 2020).
Added Author Serpa, Jacinta, editor, author.
Series Advances in experimental medicine and biology ; v. 1219.
Available in Other Form Tumor microenvironment.
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Preface
Tumor microenvironment a job of several holders
Tumor microenvironment- a selective pressure boosting cancer
Lactate and lactate transporters as key players in the maintenance of the Warburg effect
Section 1. Adaptive metabolic features are sustained by tumor microenvironment
Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis
Gut microbiota and cancer of the host: colliding interests
Metabolic plasticity of tumor cells: how they do adapt to food deprivation
Multifaceted oncogenic role of adipocytes in the tumour microenvironment
Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology
Monocytes and macrophages in cancer: unsuspected roles
Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression
Microenvironment driven metabolic adaptation in melanoma
Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis
Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt
The bone marrow niche
the tumor microenvironment that ensures leukemia progression
Section 3. Metabolic fitness and therapy response in cancer
Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer
The metabolic remodelling in lung cancer and its putative consequence in therapy response
Hydrogen sulfide metabolism and signaling in the tumor microenvironment
Using metabolic adaptation to design new drugs
Metabolomics- a new way of screening cancer
NMR as a tool for metabolomics
Section 5. Animal models- addressing cancer microenvironment
Animal models to study cancer and its microenvironment
Modulating the metabolic phenotype of cancer microenvironment
Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae
Section 6. In vitro and ex vivo cancer models
In vitro and ex vivo models- the tumor microenvironment in a flask
Index.

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