Regulation of cancer immune checkpoints : molecular and cellular mechanisms and therapy / Jie Xu.
Xu, Jie.
2020
RC268.3
Available Online

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Title Regulation of cancer immune checkpoints : molecular and cellular mechanisms and therapy / Jie Xu.
ISBN 9789811532665
9811532664
Publication Details Singapore : Springer, ©2020.
Language English
Description 1 online resource (657 pages)
Call Number RC268.3
Dewey Decimal Classification 616.994079
Summary This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Xu, Jie.
Series Advances in experimental medicine and biology ; v. 1248.
Available in Other Form Regulation of Cancer Immune Checkpoints : Molecular and Cellular Mechanisms and Therapy.
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Introduction
Molecular and cellular functions of CTLA-4 pathway
Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond
Discovery of new immune checkpoints: family grows up
Mechanisms of resistance to checkpoint blockade therapy
Molecular events behind adverse effects
Rational discovery of response biomarkers
Spatiotemporal changes in checkpoint molecule expression
Functions of checkpoint molecules beyond immune evasion
Genetic alterations and checkpoint expression
Regulations on messenger RNA: wires and nodes
Folded or degraded in endoplasmic reticulum
Mono- and poly-ubiquitination: tags for fates
Lysosome as the black hole for checkpoint molecules
Phosphorylation: a fast switch for checkpoint signalling
Palmitoylation as a signal for delivery
Checkpoints under traffic control: from and to organelles
Exosome and secretion: action on?
Macromolecules and antibody-based drugs
Mechanisms inspired targeting peptides
Small molecular inhibitors
Therapeutic development of immune checkpoint blockers
Concluding remarks.

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