@article{930308,
      recid = {930308},
      author = {Lee, Peter P., and Marincola, Francesco M.,},
      title = {Tumor microenvironment /},
      pages = {1 online resource.},
      abstract = {This book addresses the biological processes relevant to  the immune phenotypes of cancer and their significance for  immune responsiveness, based on the premise that malignant  cells manipulate their surroundings through an evolutionary  process that is controlled by interactions with innate  immune sensors as well as the adaptive recognition of  self/non-self. Checkpoint inhibitor therapy is now an  accepted new form of cancer treatment. Other  immuno-oncology approaches, such as adoptive cell therapy  and metabolic inhibitors, have also shown promising results  for specific indications. Immune resistance is common,  however, limiting the efficacy of immunotherapy in many  common cancer types. The reasons for such resistance are  diverse and peculiar to the immune landscapes of individual  cancers, and to the treatment modality used. Accordingly,  approaches to circumvent resistance need to take into  account context-specific genetic, biological and  environmental factors that may affect the cancer immune  cycle, and which can best be understood by studying the  target tissue and correlated systemic immune markers.  Understanding the major requirements for the evolutionary  process governing human cancer growth in the  immune-competent host will guide effective therapeutic  choices that are tailored to the biology of individual  cancers.},
      url = {http://library.usi.edu/record/930308},
      doi = {https://doi.org/10.1007/978-3-030-38862-1},
}