000931593 000__ 02740cam\a2200481Ia\4500 000931593 001__ 931593 000931593 005__ 20230306151523.0 000931593 006__ m\\\\\o\\d\\\\\\\\ 000931593 007__ cr\un\nnnunnun 000931593 008__ 200418s2020\\\\sz\\\\\\o\\\\\000\0\eng\d 000931593 019__ $$a1153072040$$a1153275266 000931593 020__ $$a9783030382667$$q(electronic book) 000931593 020__ $$a3030382664$$q(electronic book) 000931593 020__ $$z9783030382650 000931593 020__ $$z3030382656 000931593 0247_ $$a10.1007/978-3-030-38266-7$$2doi 000931593 035__ $$aSP(OCoLC)on1151192730 000931593 035__ $$aSP(OCoLC)1151192730$$z(OCoLC)1153072040$$z(OCoLC)1153275266 000931593 040__ $$aEBLCP$$beng$$cEBLCP$$dGW5XE$$dEBLCP$$dYDX$$dUPM 000931593 049__ $$aISEA 000931593 050_4 $$aQP551 000931593 08204 $$a572/.6$$223 000931593 24500 $$aProteostasis and disease :$$bfrom basic mechanisms to clinics /$$cRosa Barrio, James D. Sutherland, Manuel S. Rodriguez, editors. 000931593 260__ $$aCham :$$bSpringer,$$c2020. 000931593 300__ $$a1 online resource (350 pages). 000931593 336__ $$atext$$btxt$$2rdacontent 000931593 337__ $$acomputer$$bc$$2rdamedia 000931593 338__ $$aonline resource$$bcr$$2rdacarrier 000931593 347__ $$atext file$$bPDF$$2rda 000931593 4901_ $$aAdvances in Experimental Medicine and Biology ;$$vv.1233 000931593 506__ $$aAccess limited to authorized users. 000931593 520__ $$aThis book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field. 000931593 588__ $$aDescription based on print version record. 000931593 650_0 $$aProteins. 000931593 7001_ $$aBarrio, Rosa. 000931593 7001_ $$aRodriguez, Manuel S. 000931593 7001_ $$aSutherland, James D. 000931593 77608 $$iPrint version:$$aBarrio, Rosa$$tProteostasis and Disease : From Basic Mechanisms to Clinics$$dCham : Springer,c2020$$z9783030382650 000931593 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1233. 000931593 852__ $$bebk 000931593 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-38266-7$$zOnline Access$$91397441.1 000931593 909CO $$ooai:library.usi.edu:931593$$pGLOBAL_SET 000931593 980__ $$aEBOOK 000931593 980__ $$aBIB 000931593 982__ $$aEbook 000931593 983__ $$aOnline 000931593 994__ $$a92$$bISE