@article{932715,
      recid = {932715},
      author = {Bueno, Juan.},
      title = {Preclinical evaluation of antimicrobial nanodrugs /},
      publisher = {Springer,},
      address = {Cham :},
      pages = {1 online resource (125 pages).},
      year = {2020},
      abstract = {Translational medicine addresses the gap between research  and the clinical application of new discoveries. To  efficiently deliver new drugs to care centers, a  preclinical evaluation, both in vitro and in vivo, is  required to ensure that the most active and least toxic  compounds are selected as well as to predict clinical  outcome. Antimicrobial nanomedicines have been shown to  have higher specificity in their therapeutic targets and  the ability to serve as adjuvants, increasing the  effectiveness of pre-existing immune compounds. The design  and development of new standardized protocols for  evaluating antimicrobial nanomedicines is needed for both  the industry and clinical laboratory. These protocols must  aim to evaluate laboratory activity and present models of  pharmacokinetic-pharmacodynamic and toxicokinetic behavior  that predict absorption and distribution. Likewise, these  protocols must follow a theranostics approach, be able to  detect promising formulations, diagnose the infectious  disease, and determine the correct treatment to implement a  personalized therapeutic behavior. Given the possibilities  that nanotechnology offers, not updating to new screening  platforms is inadequate as it prevents the correct  application of discoveries, increasing the effect of the  valley of death between innovations and their use. This  book is structured to discuss the fundamentals taken into  account for the design of robust, reproducible and  automatable evaluation platforms. These vital platforms  should enable the discovery of new medicines with which to  face antimicrobial resistance (RAM), one of the great  problems of our time.},
      url = {http://library.usi.edu/record/932715},
      doi = {https://doi.org/10.1007/978-3-030-43,  https://doi.org/10.1007/978-3-030-43855-5},
}