Mechanisms of genome protection and repair / Dmitry O. Zharkov, editor.
Zharkov, Dmitry O.
2020
QH467
Available Online

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Title Mechanisms of genome protection and repair / Dmitry O. Zharkov, editor.
ISBN 9783030412838 (electronic book)
3030412830 (electronic book)
3030412822
9783030412821
DOI https://doi.org/10.1007/978-3-030-41283-8
Publication Details Cham : Springer, 2020.
Language English
Description 1 online resource (230 pages).
Item Number 10.1007/978-3-030-41283-8 doi
Call Number QH467
Dewey Decimal Classification 572.8/6459
Summary This volume is about DNA damage and repair. It covers recent advances in several important research areas of this rapidly expanding field, and does so at several levels, from individual molecules to organisms. The topics include mechanisms of damage recognition by DNA repair enzymes, chromatin response to DNA damage, special ways of mutagenesis, biomarkers of genotoxicity, and the integrated organism response to genotoxic and other kinds of stress. The book starts with two chapters about structural and mechanistic features of protein-DNA interactions that ensure fast and reliable discrimination between targets - be it DNA modifications or specific sequences - and non-targets. Examples of particular proteins and their function in repair regulation, translesion synthesis and chromatin remodeling are discussed in the following three chapters. Next, more attention is given to the mutagenic consequences of failed or aberrant DNA repair, particularly in mitochondria and in runs of trinucleotide repeats. Moving to a human health-oriented view, the book presents data on two kinds of lesions, the widely found 8-oxoguanine and the dietary genotoxic adducts with aristolochic acids, as biomarkers of general oxidative stress and specific exposure, respectively. Two final chapters are devoted to the interplay of multiple factors, including genotoxic stress, in the complex phenotypes in humans (amyotrophic lateral sclerosis ) and plants (abiotic stress response). This volume will be of significant interest for scientists working in the field of DNA repair as well as for the general biochemistry and molecular biology audience.
Note Includes index.
Access Note Access limited to authorized users.
Digital File Characteristics text file PDF
Source of Description Description based on print version record.
Added Author Zharkov, Dmitry O.
Series Advances in experimental medicine and biology ; v. 1241.
Available in Other Form Mechanisms of Genome Protection and Repair
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Preface
Kinetic Milestones of Damage Recognition by DNA Glycosylases of the Helix-Hairpin-Helix Structural Superfamily
Protein Engineering of DNA-Dependent Enzymes
A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis
Impact of PARP1, PARP2 and PARP3 on the Base Excision Repair of Nucleosomal DNA
Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling
DNA Repair and Mutagenesis in Vertebrate Mitochondria: Evidence for Asymmetric DNA Strand Inheritance
Mystery of Expansion: DNA Metabolism and Unstable Repeats
The Detection of 8-Oxo-7,8-Dihydro-2'-Deoxyguanosine in Circulating Cell-Free DNA: A Step Towards Longitudinal Monitoring of Health
Biotransformation and Toxicities of Aristolochic Acids
Mechanisms of Sugar Beet Response to Biotic and Abiotic Stresses
Studying ALS: Current Approaches, Effect on Potential Treatment Strategy.

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