@article{932771,
      recid = {932771},
      author = {YU, Zutao.},
      title = {Artificial assemblies with cooperative DNA recognition /},
      publisher = {Springer,},
      address = {Singapore :},
      pages = {1 online resource (145 pages).},
      year = {2020},
      note = {"Doctoral thesis accepted by Kyoto University, Kyoto,  Japan."},
      abstract = {This book presents three types of synthetically  cooperative DNA recognizing assemblies, in order to advance  the development of programmable DNA-binding  pyrrole-imidazole polyamides (PIPs). PIPs represent the  best-characterized class of small molecule DNA binders that  can be modified to bind with any predetermined DNA sequence  and regulate gene expression patterns in a transgene-free  and cost-effective manner. PIPs are characterized by their  small molecular size, high binding affinity,  programmability, sequence selectivity, and moderate cell  permeability. In recent years, there have been numerous  novel studies on the applications of these biological  tools; this research is thoroughly reviewed in the first  chapter. There are several critical issues, however, that  impede the further broad study of PIPs, which greatly  concern the author. For instance, the short PIP version has  an excessively hi^10 bp; this significantly decreases cell  permeability. Moreover, the conventional binding strategy  for PIP design cannot apply to flexible DNA binding--for  example, the DNA-binding mode of a transcription factor  pair. In this book, the author describes the development of  three kinds of cooperative DNA-binding systems that help  resolve the current highly problematic issues concerning  PIPs. These three systems offer a range of significant  advantages, such as favorable sequence selectivity, long  recognition sequence, higher binding affinity, and a  flexible gap distance. Released at a critical juncture in  the application of PIPs, this book will greatly facilitate  their use as therapeutic drugs in the treatment of cancer  and hereditary diseases, and in regenerative medicine.},
      url = {http://library.usi.edu/record/932771},
      doi = {https://doi.org/10.1007/978-981-15-4,  https://doi.org/10.1007/978-981-15-4423-1},
}