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000933286 019__ $$a1158229887$$a1159165871
000933286 020__ $$a9783030380625
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000933286 0247_ $$a10.1007/978-3-030-38062-5$$2doi
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000933286 050_4 $$aQH506$$b.M96 2020
000933286 08204 $$a611.01816$$223
000933286 24500 $$aMyosins :$$bA Superfamily of Molecular Motors /$$cedited by Lynne M. Coluccio.
000933286 250__ $$a2nd ed. 2020.
000933286 264_1 $$aCham :$$bSpringer International Publishing :$$bImprint: Springer,$$c2020.
000933286 300__ $$a1 online resource (xi, 455 pages) :$$billustrations.
000933286 336__ $$atext$$btxt$$2rdacontent
000933286 337__ $$acomputer$$bc$$2rdamedia
000933286 338__ $$aonline resource$$bcr$$2rdacarrier
000933286 347__ $$atext file$$bPDF$$2rda
000933286 4901_ $$aAdvances in Experimental Medicine and Biology,$$x0065-2598 ;$$v1239
000933286 5050_ $$aIntroduction -- Myosin Structure -- Cargo Binding by Unconventional Myosins -- Cryo-EM of Actin-Myosin Structures -- Small Molecule Effectors of Myosin Function -- Single-Molecule Biophysical Techniques to Study Actomyosin Force Transduction -- High-Speed Atomic Force Microscopy to Study Myosin Motility -- How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches -- How Actin Tracks Affect Myosin Motors -- Myosins in the Nucleus -- Myosins in Cytokinesis -- Myosins and Disease -- Myosins and Hearing -- The Actomyosin Systems in Apicomplexa -- Approaches to Identify and Characterise MYO6-Cargo Interactions -- Class IX Myosins: Motorized RhoGAP Signaling Molecules -- Myosin X -- Myosin XVI -- Myosin XVIII -- Myosin XIX.
000933286 506__ $$aAccess limited to authorized users.
000933286 520__ $$aMyosins are molecular motors that use the energy from ATP hydrolysis to move and exert tension on actin filaments. Although the best-known myosin is myosin II, which powers skeletal muscle contraction, there are at least two dozen classes of myosins, and cells generally express multiple isoforms. Myosins are involved in multiple cellular activities including cell structure, cell migration, intracellular trafficking, and cell-cell contact. Importantly, loss of function and mutation are associated with diseases including myopathies, hearing impairment, glomerulosclerosis, and cancer. Written by international experts in myosin motors and the approaches used to study them, this book is expected to provide a comprehensive assessment of the current status of our understanding of the structure and molecular mechanism of myosins and their cellular roles.
000933286 650_0 $$aMolecular biology.
000933286 650_0 $$aProteins.
000933286 650_0 $$aCytology.
000933286 7001_ $$aColuccio, Lynne M.,$$eeditor.
000933286 77608 $$iPrint version:$$z9783030380618
000933286 830_0 $$aAdvances in experimental medicine and biology ;$$v1239.
000933286 852__ $$bebk
000933286 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-38062-5$$zOnline Access$$91397441.1
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