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Current advances in the science of osteosarcoma : research perspectives: tumor biology, organ microenvironment, potential new therapeutic targets, and canine models / Eugenie S. Kleinerman, Richard Gorlick, editors.

Kleinerman, Eugenie.; Gorlick, Richard.
2020
RC280.B6 C87 2020eb
Available Online
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Title
Current advances in the science of osteosarcoma : research perspectives: tumor biology, organ microenvironment, potential new therapeutic targets, and canine models / Eugenie S. Kleinerman, Richard Gorlick, editors.
Edition
Second edition.
ISBN
9783030430856 (electronic book)
3030430855 (electronic book)
3030430847
9783030430849
DOI
https://doi.org/10.1007/978-3-030-43
Publication Details
Cham, Switzerland : Springer, 2020.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-43
Call Number
RC280.B6 C87 2020eb
Dewey Decimal Classification
616.99/471
Summary
This thoroughly revised second edition is an up-to-date overview of the new advances in the knowledge of the basic science in sarcoma and osteosarcoma. It features detailed, in-depth discussions of microRNAs in osteosarcoma, historical perspectives of chemotherapy in the treatment of the disease, tumor targeted IL12 therapy and HER2 targeted therapy, the role of enhancer elements in regulating the prometastatic transcriptional program and more. Further, this essential volume also includes new insights on Wnt signaling in osteosarcoma, the role of genomics, genetically modified T-cell therapy, liquid biopsy, oncolytic viruses, immunophenotyping, receptor tyrosine kinases and epigenetic-focused approaches for treatment of osteosarcoma metastases, as well as thoughts on the current standard of treatment for patients suffering from these cancers. In the years since the previous edition, there have been numerous new developments in this rapidly changing field; this new edition is both timely and urgently needed. When taken together these companion volumes, Current Clinical (Book 1) and Scientific (Book 2) Advances in Osteosarcoma, are a timely and urgently needed guide for laboratory investigators and clinical oncologists.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Kleinerman, Eugenie.
Gorlick, Richard.
Series
Advances in experimental medicine and biology ; v. 1258.
Available in Other Form
Print version: 9783030430849
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All Resources
The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies
Genomics and the Immune Landscape of Osteosarcoma
RECQ DNA Helicases and Osteosarcoma
Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma
Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma
Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response
Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma
Wnt Signaling in Osteosarcoma
Receptor Tyrosine Kinases in Osteosarcoma: 2019 update
The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets
Autophagy in OS
Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs
Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment
Comparative Immunology and Immunotherapy of Canine Osteosarcoma
Index.

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