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000940742 019__ $$a1183954566$$a1191076544$$a1195467892$$a1196164493$$a1197541577$$a1197548523
000940742 020__ $$a9783030497019$$q(electronic book)
000940742 020__ $$a3030497011$$q(electronic book)
000940742 020__ $$z3030497003
000940742 020__ $$z9783030497002
000940742 0247_ $$a10.1007/978-3-030-49
000940742 0247_ $$a10.1007/978-3-030-49701-9$$2doi
000940742 035__ $$aSP(OCoLC)on1184058249
000940742 035__ $$aSP(OCoLC)1184058249$$z(OCoLC)1183954566$$z(OCoLC)1191076544$$z(OCoLC)1195467892$$z(OCoLC)1196164493$$z(OCoLC)1197541577$$z(OCoLC)1197548523
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000940742 050_4 $$aRC271.R3
000940742 08204 $$a616.99/40642$$223
000940742 24500 $$aMolecular targeted radiosensitizers :$$bopportunities and challenges /$$cHenning Willers, Iris Eke, editors.
000940742 260__ $$aCham, Switzerland :$$bHumana Press,$$c2020.
000940742 300__ $$a1 online resource
000940742 336__ $$atext$$btxt$$2rdacontent
000940742 337__ $$acomputer$$bc$$2rdamedia
000940742 338__ $$aonline resource$$bcr$$2rdacarrier
000940742 4901_ $$aCancer Drug Discovery and Development Ser.
000940742 500__ $$aIncludes index.
000940742 5050_ $$aIntroduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges -- Translating Targeted Radiosensitizers into the Clinic -- Cartography of the Radiogenome of Human Cancers -- Mechanisms and Markers of Clinical Radioresistance -- Preclinical Strategies for Testing of Targeted Radiosensitizers -- 3D Radiation Biology for Identifying Radiosensitizers -- Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments -- Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers -- Targeting the DNA Damage Response for Radiosensitization -- Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia -- Normalizing the Tumor Microenvironment for Radiosensitization -- Radiosensitizers in the Era of Immuno-Oncology -- Index.
000940742 506__ $$aAccess limited to authorized users.
000940742 520__ $$aMolecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
000940742 650_0 $$aCancer$$xRadiotherapy$$xMolecular aspects.
000940742 650_0 $$aRadiation-sensitizing agents.
000940742 7001_ $$aWillers, Henning.
000940742 7001_ $$aEke, Iris.
000940742 77608 $$iPrint version:$$z3030497003$$z9783030497002$$w(OCoLC)1154101782
000940742 830_0 $$aCancer Drug Discovery and Development Ser.
000940742 852__ $$bebk
000940742 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-49701-9$$zOnline Access$$91397441.1
000940742 909CO $$ooai:library.usi.edu:940742$$pGLOBAL_SET
000940742 980__ $$aEBOOK
000940742 980__ $$aBIB
000940742 982__ $$aEbook
000940742 983__ $$aOnline
000940742 994__ $$a92$$bISE