Molecular targeted radiosensitizers : opportunities and challenges / Henning Willers, Iris Eke, editors.
Willers, Henning.; Eke, Iris.
2020
RC271.R3
Available Online

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Title Molecular targeted radiosensitizers : opportunities and challenges / Henning Willers, Iris Eke, editors.
ISBN 9783030497019 (electronic book)
3030497011 (electronic book)
3030497003
9783030497002
DOI https://doi.org/10.1007/978-3-030-49
https://doi.org/10.1007/978-3-030-49701-9
Publication Details Cham, Switzerland : Humana Press, 2020.
Language English
Description 1 online resource
Item Number 10.1007/978-3-030-49
10.1007/978-3-030-49701-9 doi
Call Number RC271.R3
Dewey Decimal Classification 616.99/40642
Summary Molecular Targeted Radiosensitizers: Opportunities and Challenges provides the reader with a comprehensive review of key pre-clinical research components required to identify effective radiosensitizing drugs. The book features discussions on the mechanisms and markers of clinical radioresistance, pre-clinical screening of targeted radiosensitizers, 3D radiation biology for studying radiosensitizers, in vivo determinations of local tumor control, genetically engineered mouse models for studying radiosensitizers, targeting the DNA damage response for radiosensitization, targeting tumor metabolism to overcome radioresistance, radiosensitizers in the era of immuno-oncology, and more. Additionally, the book features discussions on high-throughput drug screening, predictive biomarkers, pre-clinical tumor models, and the influence of the tumor microenvironment and the immune system, with a specific focus on the challenges radiation oncologists and medical oncologists currently face in testing radiosensitizers in human cancers. Edited by two acclaimed experts in radiation biology and radiosensitizers, with thirteen chapters contributed by experts, this new volume presents an in-depth look at current developments within a rapidly moving field, with a look at where the field will be heading and providing comprehensive insight into the framework of targeted radiosensitzer development. Essential reading for investigators in cancer research and radiation biology.
Note Includes index.
Access Note Access limited to authorized users.
Added Author Willers, Henning.
Eke, Iris.
Series Cancer Drug Discovery and Development Ser.
Available in Other Form Print version: 9783030497002
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Introduction to Molecular Targeted Radiosensitizers: Opportunities and Challenges
Translating Targeted Radiosensitizers into the Clinic
Cartography of the Radiogenome of Human Cancers
Mechanisms and Markers of Clinical Radioresistance
Preclinical Strategies for Testing of Targeted Radiosensitizers
3D Radiation Biology for Identifying Radiosensitizers
Preclinical in vivo evaluation of novel radiosensitizers by local tumor control experiments
Genetically Engineered Mouse Models for Studying Radiation Biology and Radiosensitizers
Targeting the DNA Damage Response for Radiosensitization
Targeting Tumor Metabolism to Overcome Radioresistance.-Targeting Tumor Hypoxia
Normalizing the Tumor Microenvironment for Radiosensitization
Radiosensitizers in the Era of Immuno-Oncology
Index.

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