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000941111 020__ $$a9783030053369$$q(electronic book)
000941111 020__ $$a3030053369$$q(electronic book)
000941111 020__ $$z3030053350
000941111 020__ $$z9783030053352
000941111 035__ $$aSP(OCoLC)on1192494236
000941111 035__ $$aSP(OCoLC)1192494236
000941111 040__ $$aYDX$$beng$$cYDX$$dSFB
000941111 049__ $$aISEA
000941111 050_4 $$aR857.T55
000941111 08204 $$a612.028$$223
000941111 24500 $$aTissue-engineered vascular grafts.
000941111 260__ $$a[Place of publication not identified],$$bSPRINGER NATURE,$$c2020.
000941111 300__ $$a1 online resource
000941111 336__ $$atext$$btxt$$2rdacontent
000941111 337__ $$acomputer$$bc$$2rdamedia
000941111 338__ $$aonline resource$$2rdacarrier
000941111 5050_ $$a1. Clinical Aspects and Limitations of Vascular Grafts (Peter ZILLA, SA) -- 2. Synthetic Materials for Vascular Scaffolds -- 3. Mechanical Testing of Vascular Grafts (Christian GRASL and Martin STOIBER, Heinz SCHIMA, AU) -- 4. In vitro Testing of Engineered Vascular Grafts -- 5. In Vivo Testing and Animal Models for Vascular Grafts (Helga BERGMEISTER, AU, Bruno PODESSER, AU) -- 6. Decellularized Vascular Grafts for VTE (Axel HAVERICH, Sotiris KOROSSIS, Andres HILFIKER, DE) -- 7. Degradable and Non-degradable Vascular Scaffolds (Yadong WANG, William WAGNER, USA) -- 8. In Vivo Vascular Tissue Engineering -- Long-term Results (Beat WALPOTH, CH) -- 9. Cell-Assembled Extracellular Matrix for Building Vascular Grafts (Nicolas L'HEUREUX, FR) -- 10. Cell-based/Seeding of Vascular Grafts (David VORP, Justin Sol WEINBAUM, Darren G HASKETT, USA) -- 11. Vascular Tissue Engineering: the role of 3-D printing (Ali KHADEMHOSSEINI, Yu Shrike ZHANG, USA) -- 12. Autologous Mandril-based VTE (Joris ROTMANS, NL) -- 13. The Role of Tropoelastin in VTE (Tony WEISS, AUS) -- 14. Vascular Grafts made of Cell Sheets -- 15. Vascular Tissue Engineering: Pathology, Mechanisms, and Translational Implications (Carlijn BOUTEN, NL, Fred SCHOEN, USA) -- 16. Models to study cardiovascular calcification relevant to tissue engineering (Elena AIKAWA, USA) -- 17. The incorporation and release of bioactive molecules in Vascular Grafts (Deling KONG, CN) -- 18. Functionalization/Coating of Vascular Grafts" including "cell surface interaction" (Olivier FELIX, Gero DECHER, FR, Mitsuru AKASHI, JP) -- 19. Clinical application of VTE for children (Toshi SHINOKA, Christopher BREUER, USA) -- 20. Bioengineered Human Acellular Vessels (Laura NIKLASON, Jeffrey H. LAWSON, USA).
000941111 506__ $$aAccess limited to authorized users.
000941111 520__ $$aCardiovascular diseases are still the leading cause of death in developed countries. Revascularization procedures such as coronary artery and peripheral bypass grafts, as well as access surgery represent a 2$ billion market yearly for the US alone. Despite intense research over many decades, no clinically suitable, shelf-ready, synthetic, vascular, small-caliber graft exists. There is therefore still a quest for such a clinical vascular prosthesis for surgical revascularization procedures and access surgery. Many approaches have been tried and are currently under investigation with promising results. These range from acellular and cell-based, stable or bio-degradable, synthetic scaffolds to biological or decellularized grafts, not forgetting self-assembly technologies for in vitro or in vivo VTE. All these approaches can be further enhanced by functionalization, e.g. with growth factors and drug elution. This updatable book aims to cover all the relevant aspects of Vascular Tissue Engineering (VTE) and novel alternatives to develop vascular grafts for clinical applications. The chapters in this book cover different aspects of manufacturing scaffolds with various polymers, mechanical characteristics, degradation rates, decellularization techniques, cell sheet assembly, 3-D printing and autologous mandril-based VTE. All the necessary in vitro tests such as biocompatibility and thrombogenicity are reviewed. Pre-clinical assessment of in vivo experimental models include patency, compliance, intimal hyperplasia, inflammatory reaction, cellular ingrowth and remodeling. Finally, early clinical trials will be periodically updated regarding results, regulatory aspects and post-marketing quality assessment. Furthermore, the reader should get an insight into various approaches, technologies and methods to better understand the complexity of blood surface and cell interactions in VTE. Translational research has yielded early human applications clearly showing the enormous need of research in the field to provide better solutions for our patients and this continuously updated book will hopefully become a reference in the field for life sciences.
000941111 650_0 $$aRegenerative medicine.
000941111 650_0 $$aTissue engineering.
000941111 650_0 $$aBiomedical engineering.
000941111 650_0 $$aSurgery.
000941111 650_0 $$aBiomaterials.
000941111 77608 $$iPrint version:$$z3030053350$$z9783030053352$$w(OCoLC)1061820290
000941111 852__ $$bebk
000941111 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-05336-9$$zOnline Access$$91397441.1
000941111 909CO $$ooai:library.usi.edu:941111$$pGLOBAL_SET
000941111 980__ $$aEBOOK
000941111 980__ $$aBIB
000941111 982__ $$aEbook
000941111 983__ $$aOnline
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