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000943849 019__ $$a1197554193$$a1197845253$$a1198392423$$a1200578610
000943849 020__ $$a9783030506216$$q(electronic book)
000943849 020__ $$a3030506215$$q(electronic book)
000943849 020__ $$z3030506207
000943849 020__ $$z9783030506209
000943849 0247_ $$a10.1007/978-3-030-50621-6$$2doi
000943849 0248_ $$a10.1007/978-3-030-50
000943849 035__ $$aSP(OCoLC)on1195920816
000943849 035__ $$aSP(OCoLC)1195920816$$z(OCoLC)1197554193$$z(OCoLC)1197845253$$z(OCoLC)1198392423$$z(OCoLC)1200578610
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000943849 049__ $$aISEA
000943849 050_4 $$aQP751
000943849 050_4 $$aQH506$$b.D78 2020
000943849 08204 $$a612/.01577$$223
000943849 08204 $$a611.01816$$223
000943849 24500 $$aDruggable lipid signaling pathways /$$cYasuyuki Kihara, editor.
000943849 260__ $$aCham, Switzerland :$$bSpringer,$$c2020.
000943849 300__ $$a1 online resource
000943849 336__ $$atext$$btxt$$2rdacontent
000943849 337__ $$acomputer$$bc$$2rdamedia
000943849 338__ $$aonline resource$$bcr$$2rdacarrier
000943849 4901_ $$aAdvances in experimental medicine and biology ;$$vv.1274
000943849 500__ $$aIncludes index.
000943849 5050_ $$aPreface -- Introduction of Druggable Lipid Signaling Pathway -- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development -- Druggable Prostanoid Pathway -- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress -- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation -- Druggable Sphingolipid Pathway -- Druggable Lysophospholipid Pathway -- Druggable targets in endocannabinoid signaling -- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections -- Druggable Lipid GPCRs: Past, Present, and Prospects.
000943849 506__ $$aAccess limited to authorized users.
000943849 520__ $$aThis edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs. Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs.
000943849 650_0 $$aLipids.
000943849 650_0 $$aCellular signal transduction.
000943849 650_0 $$aPharmacology.
000943849 650_0 $$aMolecular biology.
000943849 650_0 $$aDiagnosis, Laboratory.
000943849 650_0 $$aHuman genetics.
000943849 650_0 $$aCancer$$xResearch.
000943849 7001_ $$aKihara, Yasuyuki.
000943849 77608 $$iPrint version: $$z3030506207$$z9783030506209$$w(OCoLC)1154859635
000943849 830_0 $$aAdvances in experimental medicine and biology ;$$vv. 1274.
000943849 852__ $$bebk
000943849 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=https://dx.doi.org/10.1007/978-3-030-50621-6$$zOnline Access
000943849 909CO $$ooai:library.usi.edu:943849$$pGLOBAL_SET
000943849 980__ $$aEBOOK
000943849 980__ $$aBIB
000943849 982__ $$aEbook
000943849 983__ $$aOnline
000943849 994__ $$a92$$bISE