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000945123 0247_ $$a10.1007/978-3-030-48405-7.$$2doi
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000945123 08204 $$a614.5999$$223
000945123 24500 $$aPhytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers /$$cedited by Ganji Purnachandra Nagaraju.
000945123 250__ $$a1st ed. 2020.
000945123 264_1 $$aCham :$$bSpringer International Publishing :$$bImprint: Springer,$$c2020.
000945123 300__ $$a1 online resource (XI, 340 pages) :billustrations.
000945123 336__ $$atext$$btxt$$2rdacontent
000945123 337__ $$acomputer$$bc$$2rdamedia
000945123 338__ $$aonline resource$$bcr$$2rdacarrier
000945123 5050_ $$aRole of specific phytochemicals against gastrointestinal malignancies -- Role of phytochemicals on growth and metastasis of GI cancer -- Cancer Stem Cells as Therapeutic Targets for Gastrointestinal cancers -- Phytochemicals plus checkpoint inhibitors in GI cancers -- Crucial role of curcumin on gut microbiota associated with GI cancers -- Cellular and Molecular mechanisms of garlic compounds in common GI cancers -- Combination of Phytochemicals with Nanotechnology for Targeting GI Cancer Therapy -- Emerging Roles of Phytochemicals in the Pathobiology and Management of Esophageal Cancer -- Gastric Cancer: Role of Phytochemicals and Tyrosine Kinase Inhibitors -- Therapeutic Efects Of Curcumin Against Colorectal Cancer -- Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes -- Role of Dietary Supplementation of Natural products in the Prevention and Treatment of Liver Diseases -- Emerging Roles of Phytochemicals in Hepatocellular Carcinoma -- Phytochemicals: Current Understandings of the Modern Therapeutic Approaches for Hepatocellular Carcinoma -- Index.
000945123 506__ $$aAccess limited to authorized users.
000945123 520__ $$aGastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor's increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor's specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.
000945123 650_0 $$aCancer$$xResearch.
000945123 650_0 $$aOncology.
000945123 7001_ $$aNagaraju, Ganji Purnachandra,$$eeditor.
000945123 77608 $$iPrint version:$$aNagaraju, Ganji Purnachandra$$tPhytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers$$dCham : Springer International Publishing AG,c2020
000945123 852__ $$bebk
000945123 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-48405-7$$zOnline Access$$91397441.1
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000945123 980__ $$aBIB
000945123 982__ $$aEbook
000945123 983__ $$aOnline
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