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000945131 0247_ $$a10.1007/978-3-030-44743-4.$$2doi
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000945131 24504 $$aThe Chemical Biology of Long Noncoding RNAs /$$cedited by Stefan Jurga, Jan Barciszewski.
000945131 250__ $$a1st ed. 2020.
000945131 264_1 $$aCham :$$bSpringer International Publishing :$$bImprint: Springer,$$c2020.
000945131 300__ $$a1 online resource (X, 544 pages) :$$billustrations.
000945131 336__ $$atext$$btxt$$2rdacontent
000945131 337__ $$acomputer$$bc$$2rdamedia
000945131 338__ $$aonline resource$$bcr$$2rdacarrier
000945131 4901_ $$aRNA Technologies,$$x2197-9731 ;$$v11
000945131 506__ $$aAccess limited to authorized users.
000945131 520__ $$aThis book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.
000945131 650_0 $$aHuman genetics.
000945131 650_0 $$aNucleic acids.
000945131 650_0 $$aBiomedical engineering.
000945131 7001_ $$aJurga, Stefan,$$eeditor.
000945131 7001_ $$aBarciszewski, Jan,$$eeditor.
000945131 77608 $$iPrint version: $$z3030447421$$z9783030447427$$w(OCoLC)1143619266
000945131 830_0 $$aRNA technologies,$$x2197-9731 ;$$v11.
000945131 852__ $$bebk
000945131 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-3-030-44743-4$$zOnline Access$$91397441.1
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000945131 980__ $$aEBOOK
000945131 980__ $$aBIB
000945131 982__ $$aEbook
000945131 983__ $$aOnline
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