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000945133 0247_ $$a10.1007/978-981-15-7793-2.$$2doi
000945133 035__ $$aSP(OCoLC)on1203350938
000945133 035__ $$aSP(OCoLC)1203350938$$z(OCoLC)1200494783$$z(OCoLC)1202474760
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000945133 050_4 $$aRC902-918
000945133 08204 $$a616.61$$223
000945133 24500 $$aUremic Toxins and Organ Failure /$$cedited by Hideyuki Saito, Takaaki Abe.
000945133 250__ $$a1st ed. 2020.
000945133 264_1 $$aSingapore :$$bSpringer Singapore :$$bImprint: Springer,$$c2020.
000945133 300__ $$a1 online resource (VIII, 180 pages) :$$billustrations.
000945133 336__ $$atext$$btxt$$2rdacontent
000945133 337__ $$acomputer$$bc$$2rdamedia
000945133 338__ $$aonline resource$$bcr$$2rdacarrier
000945133 5050_ $$a1 Overview of Uremic Toxins -- 2 Review: Uremic toxins and gut microbiome -- 3 Gut microbiota and systemic uremic solute accumulation -- 4 Uremic toxin-related systemic disorders -- 5 Uremic Toxins and cardiovascular disease -- 6 Indoxyl sulfate and arteriosclerosis -- 7 Uremic Toxicity and Bone in CKD -- 8 D-serine as a novel uremic toxin -- 9 Uremic solutes and sarcopenia -- 10 Toxico-pathological role of hepatic sulfotransferase (SULT) 1A1 in acute kidney injuries -- 11 Accumulation of uremic toxins in systemic organs and the effect of AST-120.
000945133 506__ $$aAccess limited to authorized users.
000945133 520__ $$aThis book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.
000945133 650_0 $$aNephrology.
000945133 650_0 $$aGastroenterology.
000945133 650_0 $$aCardiology.
000945133 7001_ $$aSaito, Hideyuki.,$$eeditor.
000945133 7001_ $$aAbe, Takaaki.,$$eeditor.
000945133 77608 $$iPrint version: $$z9811577927$$z9789811577925$$w(OCoLC)1164500428
000945133 852__ $$bebk
000945133 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-15-7793-2$$zOnline Access$$91397441.1
000945133 909CO $$ooai:library.usi.edu:945133$$pGLOBAL_SET
000945133 980__ $$aEBOOK
000945133 980__ $$aBIB
000945133 982__ $$aEbook
000945133 983__ $$aOnline
000945133 994__ $$a92$$bISE