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000946919 050_4 $$aQH301-705
000946919 1001_ $$aSingh, Shailza.
000946919 24500 $$aMetagenomic systems biology :$$bintegrative analysis of the microbiome /$$cShailza Singh, editor.
000946919 264_1 $$aSingapore :$$bSpringer,$$c[2020]
000946919 300__ $$a1 online resource (0 pages)
000946919 336__ $$atext$$btxt$$2rdacontent
000946919 337__ $$acomputer$$bc$$2rdamedia
000946919 338__ $$aonline resource$$bcr$$2rdacarrier
000946919 5050_ $$aIntro -- Contents -- About the Editor -- 1: Gut Microbiome in Microbial Pathogenicity -- 1.1 Introduction -- 1.2 Gut Microbiota and Gut Immunology -- 1.3 How Gut Microbiota Helps in Pathogen Resistance -- 1.4 Direct Mechanism by Gut Microflora for Colonization Resistance -- 1.5 The Intestine Serves as Barrier -- 1.6 Role of Gut Microbiota in Virulence of Pathogen -- 1.7 Evolving Microbiota and Drug Interaction for Personalized Medicine -- 1.8 Effect of Gut Microbiota on Drug Efficacy, Metabolism and Toxicity
000946919 5058_ $$a1.9 Few Studies of Drug Metabolism Influencing Their Activity and Toxicity by Microbes -- 1.10 How Microbes Manipulate the Response of Immunomodulatory Drugs? -- 1.11 Modifying Gut Microbiota for Précised Medicine -- 1.12 New Insights -- References -- 2: Role of Genome-Wide Association Studies in Host Genetics: Toward Understanding of Microbiome Association -- 2.1 Introduction -- 2.2 Diversity of Microbiomes -- 2.3 The Human Microbiome: Functional Link with Health and Diseases -- 2.4 Mechanistic Connection of Human Health and Dysbiosis: mGWAS Studies -- 2.5 Genesis of Diseases with Dysbiosis
000946919 5058_ $$a2.6 mGWAS: Approaches and Tools -- 2.7 Current Challenges Underpinning mGWAS -- 2.8 Concluding Remark and Prospects -- References -- 3: Understanding Microbiome Science Through Big Data Analysis -- 3.1 Introduction -- 3.1.1 The Origin of the Term ``Microbiome ́́ -- 3.1.2 The Study of the Microbiome -- 3.2 Microbiome Big Data -- 3.2.1 Shotgun Sequencing -- 3.2.2 Metatranscriptomics -- 3.3 Roche 454 Genome Sequencing -- 3.4 Illumina -- 3.5 Qiagen Gene Reader -- 3.6 Ion Torrent Sequencing Technology -- 3.7 SMRT Sequencing -- 3.8 Oxford Nanopore Sequencing
000946919 5058_ $$a3.8.1 Getting Insights from the Microbiome Data -- 3.9 Status of Microbiome Data Science -- 3.10 Tools to Study Microbiome Big Data -- 3.10.1 QIIME 2 -- 3.10.1.1 Input -- 3.10.1.2 Output -- 3.10.1.3 Workflow -- 3.10.1.4 Pros and Cons -- 3.10.2 Mothur -- 3.10.2.1 Input -- 3.10.2.2 Output -- 3.10.2.3 Workflow -- 3.10.2.4 Pros and Cons -- 3.10.3 Qiita -- 3.10.3.1 Input -- 3.10.3.2 Output -- 3.10.3.3 Pros and Cons -- 3.10.4 Megan -- 3.10.4.1 Input -- 3.10.4.2 Output -- 3.10.4.3 Pros and Cons -- 3.10.5 MicrobiomeAnalyst -- 3.10.5.1 Input -- 3.10.5.2 Output -- 3.10.5.3 Pros and Cons -- 3.10.6 iMAP
000946919 5058_ $$a3.10.6.1 Input -- 3.10.6.2 Output -- 3.10.6.3 Pros and Cons -- 3.10.7 MIMIX -- 3.10.7.1 Input -- 3.10.7.2 Output -- 3.10.7.3 Pros and Cons -- 3.11 Conclusions -- References -- 4: Comparative Genomics Facilitates Drug Target Selection and Develops Intervention Strategies Against Leishmania Infections -- 4.1 Introduction -- 4.2 Treatment Regimen of Leishmaniasis with Historical Perspective -- 4.3 Leishmania Genome Project and Sequencing of the Various Leishmania Species -- 4.3.1 Why Leishmania major Friedlin Was Selected as the Reference Strain?
000946919 506__ $$aAccess limited to authorized users.
000946919 588__ $$aDescription based on print version record.
000946919 655_0 $$aElectronic books
000946919 7001_ $$aSingh, Shailza,$$eeditor.
000946919 77608 $$iPrint version:$$aSingh, Shailza$$tMetagenomic Systems Biology : Integrative Analysis of the Microbiome$$dSingapore : Springer Singapore Pte. Limited,c2021$$z9789811585616
000946919 852__ $$bebk
000946919 85640 $$3SpringerLink$$uhttps://univsouthin.idm.oclc.org/login?url=http://link.springer.com/10.1007/978-981-15-8562-3$$zOnline Access$$91397441.1
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000946919 980__ $$aBIB
000946919 982__ $$aEbook
000946919 983__ $$aOnline
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