The pulmonary neuroepithelial body microenvironment : a multifunctional unit in the airway epithelium / Inge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen.
Brouns, Inge, author.; Verckist, Line, author.; Pintelon, Isabel, author.; Timmermans, Jean-Pierre, author.; Adriaensen, Dirk, author.
2021
QP88.45
Available Online

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Title The pulmonary neuroepithelial body microenvironment : a multifunctional unit in the airway epithelium / Inge Brouns, Line Verckist, Isabel Pintelon, Jean-Pierre Timmermans, Dirk Adriaensen.
Author Brouns, Inge, author.
ISBN 9783030658175 (electronic bk.)
3030658171 (electronic bk.)
9783030658168 (print)
3030658163
DOI https://doi.org/10.1007/978-3-030-65817-5
Published Cham, Switzerland : Springer, [2021]
Language English
Description 1 online resource (xviii, 99 pages) : illustrations (some color)
Item Number 10.1007/978-3-030-65817-5 doi
Call Number QP88.45
Dewey Decimal Classification 616.02/774
Summary This monograph sheds new light on pulmonary sensory receptors. Diving into the pulmonary microenvironment, the book focuses on the role of pulmonary neuroepithelial bodies (NEBs) as potential receptors and effectors, able to store and release neurotransmitters. It explores NEBs as potential stem cell niche and highlights the multidisciplinary approach taken to identify and study NEBs, including functional morphological investigation, live cell imaging, genetic models, and laser microdissection combined with gene expression analysis. Complexly organized NEBs are an integral part of the intrapulmonary airway epithelium of all air-breathing vertebrates. For decades a quest has been going on to unravel the functional significance of these intriguing structures that appear to be modified in the course of many pulmonary diseases. The NEB microenvironment (ME) is composed of organoid clusters of pulmonary neuroendocrine cells (PNECs) that are able to store and release neurotransmitters and are closely contacted by extensive nerve terminals, emphasizing a potential receptor/effector role and probable signalling to the central nervous system. PNECs are largely shielded from the airway lumen by a special type of Clara cells, the Clara-like cells, with potential stem cell characteristics. So far, functional studies of the pulmonary NEB ME revealed that PNECs can be activated by various mechanical and chemical stimuli, resulting in a calcium-mediated release of neurotransmitters. In the past decades, a number of publications have exposed NEBs as potential hypoxia sensors. Recent experimental evidence unveiled that the NEB ME is a quiescent stem cell niche in healthy postnatal lungs, and silencing may involve bone morphogenetic protein signalling mediated by vagal afferents. Only an integrated approach that takes all current information into account will be able to explain the full role of the pulmonary NEB ME in health and disease. This highly informative and carefully presented book, provides insights for researchers, PhD students with an interest in (bio)medical and veterinary science, especially in the field of the autonomic innervation of the lung, chemo-and mechanoreceptors.
Bibliography, etc. Note Includes bibliographical references.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed May 11, 2021).
Added Author Verckist, Line, author.
Pintelon, Isabel, author.
Timmermans, Jean-Pierre, author.
Adriaensen, Dirk, author.
Series Advances in anatomy, embryology, and cell biology ; v. 233. 0301-5556
Available in Other Form Pulmonary neuroepithelial body microenvironment.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Pulmonary sensory receptors
The pulmonary NEB ME is a complex intraepithelial unit
Studying the pulmonary NEB ME: a multidisciplinary approach
Functional exploration of the pulmonary NEB ME
Concluding remarks and future perspectives
References
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