Intro
Preface
Contents
About the Editors
Chapter 1: Application of Single Cell Technology in Colorectal Cancer
1.1 Introduction
1.2 Isolation Methods for Single Cells and Recent Developments in Single Cell Techniques
1.2.1 Single Cell Genome (DNA) Sequencing
1.2.2 Single Cell Transcriptome (RNA) Sequencing
1.2.3 Single Cell Epigenome Sequencing: DNA Methylation and Histone Sequencing
1.3 Applications
1.4 Conclusion
References
Chapter 2: Dietary Habits and Global Incidence of Colon Cancer
2.1 Introduction
2.2 The Difference in Dietary Habits

2.2.1 The Western Diet
2.2.2 Mediterranean Diet (MeD)
2.2.3 African Diet
2.2.4 Asian Diet
2.2.4.1 Chinese Diet
2.2.4.2 Japanese Diet
2.3 Fruits and Vegetables (F & V)
2.3.1 Dietary Fiber
2.4 Grains
2.5 Meat
2.6 Carcinogens Produced by Cooking Methods
2.6.1 Barbecue (BBQ)/Grilling
2.6.2 Frying
2.6.3 Roasting
2.7 Carcinogen from Food Processing
2.8 Carcinogen from Food Preservation
2.8.1 Salt
2.8.2 Monosodium Glutamate (MSG)
2.9 Carcinogen from Pesticide Uses
2.10 Environment Pollutants
2.10.1 Aflatoxins (AFB1)
2.11 Carcinogen from Water

2.12 Role of Lifestyle Factors
2.12.1 Obesity
2.12.2 Physical Inactivity
2.12.3 Alcohol Consumption
2.12.4 Smoking
2.13 Immune Status
2.14 Conclusion
References
Chapter 3: Diet and Colon Cancer: A Comprehensive Review
3.1 Introduction
3.2 Role of Nutrients in CRC
3.3 Calcium
3.4 Vitamin D
3.5 Dietary Fiber
3.6 Foods
3.7 Meat
3.8 Dairy Products
3.9 Fruits and Vegetables
3.10 Whole Grain
3.11 Dietary Pattern
3.12 Conclusion and Future Direction
References
Chapter 4: Recent Therapeutic Strategies for the Treatment of Colon Cancer

4.1 Introduction
4.2 Molecular Aspects of Colon Cancer
4.3 Diagnostic and Therapeutic Targets of Colorectal Cancer
4.3.1 Treatment Approaches to Colon Cancer
4.3.1.1 Conventional Methods
Surgery/Polypectomy
Radiation Therapy
Chemotherapy
Targeted Therapy
4.3.1.2 Advanced Approaches to Treat Colon Cancer
Immunotherapy
Cancer Vaccines
Cellular Therapies
Gene Therapies
Combination Therapies
Nutritional Supplement Therapies
References
Chapter 5: Role of Bacteria in the Development of Cancer
5.1 Introduction

5.2 Bacterial Factors Involved in Cancer Development
5.2.1 Cell Surface Components
5.2.2 Bacterial Toxins
5.2.3 Bacterial Effector Proteins
5.2.4 Other Factors
5.3 Bacterial Species Involved in Colon Cancer Development
5.3.1 Escherichia coli
5.3.2 Salmonella enterica
5.3.3 Fusobacterium nucleatum
5.3.4 Bacteroides fragilis
5.3.5 Streptococcus gallolyticus
5.3.6 Enterococcus faecalis
5.4 Conclusions
References
Chapter 6: Role of Bacterial Infection (H. pylori) in Colon Carcinogenesis and Therapeutic Approaches
6.1 Introduction
6.1.1 Colorectal Polyp