Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks
Title
The role of glycosylation in health and disease / edited by Gordan Lauc, Irena Trbojević-Akmačić.
ISBN
9783030701154 (electronic bk.)
3030701158 (electronic bk.)
303070114X
9783030701147
Publication Details
Cham, Switzerland : Springer, 2021.
Language
English
Description
1 online resource
Item Number
10.1007/978-3-030-70115-4 doi
Call Number
QP552.G59
Dewey Decimal Classification
572/.567
Summary
Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycanns' functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
Note
Includes index.
Access Note
Access limited to authorized users.
Digital File Characteristics
text file
PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed September 20, 2021).
Series
Advances in experimental medicine and biology ; v. 1325. 2214-8019
N-glycosylation
Mucin type O-GalNAc glycosylation in health and disease
Glycosphingolipids
Glycosaminoglycans
Other types of glycosylation
Extracellular vesicles and glycosylation
Quantitative genetics of human protein N-glycosylation
Epigenetic regulation of glycosylation
Glycosaminoglycans in neurodegenerative diseases
Glycosylation in autoimmune diseases
The role of glycosylation in infectious diseases
The importance of glycosylation in COVID-19 infection
The role of glycosylation in inflammatory diseases
Protein glycosylation in diabetes
Glycosylation and cardiovascular diseases
Glycosylation profiling as a biomarker of suboptimal health for chronic disease stratification
Glycosylation and aging.
