Heat shock proteins of malaria / Addmore Shonhai, Didier Picard, Gregory L. Blatch, editors.
Shonhai, Addmore, editor.; Picard, Didier, editor.; Blatch, Gregory L., editor.
2021
QR201.M3 H43 2021
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Title
Heat shock proteins of malaria / Addmore Shonhai, Didier Picard, Gregory L. Blatch, editors.
Edition
Second edition.
ISBN
9783030783976 (electronic bk.)
3030783979 (electronic bk.)
9783030783969
3030783960
DOI
https://doi.org/10.1007/978-3-030-78397-6
Published
Cham : Springer, [2021]
Copyright
©2021
Language
English
Description
1 online resource : color illustrations
Item Number
10.1007/978-3-030-78397-6 doi
Call Number
QR201.M3 H43 2021
Dewey Decimal Classification
616.9/362
Summary
This new edition describes the role of heat shock proteins in the life cycle of malaria parasites, particularly in the context of intracellular parasite stages. Thoroughly revised, this work provides a general introduction to the structural and functional features of heat shock proteins with a special focus on their role as molecular chaperones in ensuring protein quality control. The emphasis is on the heat shock protein families from Plasmodium falciparum, and their role in proteostasis and the development of malaria pathology. Moreover, the authors explore the latest prospects of targeting heat shock proteins in antimalarial drug discovery either directly or in combination therapies. Readers will experience a functional analysis of the individual families of heat shock proteins and their cooperation in functional networks, including both the parasite-resident proteome and the exportome released into host cells during intracellular stages. Subcellular and extracellular organelles such as the apicoplast and the Maurer Clefts associated with Plasmodium species are discussed in detail. The book highlights the role of heat shock proteins in the development and function of these structures. Biochemical expertise and the inclusion of novel therapeutic solutions make this collection a unique reference for experts in heat shock protein research, parasitology and infectious diseases, cell stress, molecular biology and drug discovery. Not least, advances in malaria control will contribute to ending epidemics and ensuring healthy lives in line with the UN Sustainable Development Goals.
Note
Includes index.
Access Note
Access limited to authorized users.
Source of Description
Description based on print version record.
Added Author
Shonhai, Addmore, editor.
Picard, Didier, editor.
Blatch, Gregory L., editor.
Series
Advances in experimental medicine and biology ; v. 1340. 2214-8019
Available in Other Form
Heat shock proteins of malaria.
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Chapter 1. Introductory Chapter: The Importance of Heat Shock Proteins in Survival and Pathogenesis of the Malaria Parasite Plasmodium falciparum
Chapter 2. General Structural and Functional Features of Molecular Chaperones
Chapter 3. The Role of Hsp70s in the Development and Pathogenicity of Plasmodium falciparum
Chapter 4. Role of the J Domain Protein Family in the Survival and Pathogenesis of Plasmodium falciparum. Chapter 5. Role of Hsp90 in Plasmodium falciparum Malaria
Chapter 6. The Role of Malaria Parasite Heat Shock Proteins in Protein Trafficking and Remodelling of Red Blood Cells
Chapter 7. Role of Heat Shock Proteins in Immune Modulation in Malaria
Chapter 8. Bioprospecting for Novel Heat Shock Protein Modulators: The New Frontier for Antimalarial Drug Discovery?
Chapter 9. Heat Shock Proteins as Targets for Novel Antimalarial Drug Discovery
Chapter 10
Heat Shock Proteins of Malaria: Highlights and Future Prospects.

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