Antibody glycosylation / Marija Pezer, editor.
Pezer, Marija, editor.
2021
QR186.8.G2
Available Online

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Title Antibody glycosylation / Marija Pezer, editor.
ISBN 9783030769123 (electronic bk.)
3030769127 (electronic bk.)
9783030769116 (print)
3030769119
DOI https://doi.org/10.1007/978-3-030-76912-3
Published Cham, Switzerland : Springer, 2021.
Language English
Description 1 online resource (xii, 587 pages) : illustrations (some color)
Item Number 10.1007/978-3-030-76912-3 doi
Call Number QR186.8.G2
Dewey Decimal Classification 571.9/67
Summary This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Access Note Access limited to authorized users.
Digital File Characteristics text file
PDF
Source of Description Online resource; title from PDF title page (SpringerLink, viewed October 27, 2021).
Added Author Pezer, Marija, editor.
Series Experientia supplementum (2009) ; v. 112. 2504-3692
Available in Other Form Antibody glycosylation.
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Microheterogeneity of antibody molecules
Part I: Analytical Methods
Lectin and LC based methods for immunoglobulin (G) glycosylation analysis
Mass spectrometry-based methods for immunoglobulin G N-glycosylation analysis
CE based methods for Ig(G) glycosylation analysis
Automation of Ig glycosylation analysis
Bioinformatics in immunoglobulin glycosylation analysis
Part II: Biosynthesis & Regulation
N-glycan biosynthesis: Basic principles and factors affecting its outcome
Genetic regulation of immunoglobulin G glycosylation
Epigenetics of immunoglobulin G glycosylation
IgG changes in aging and other inflammatory conditions
Estrogen-driven changes in immunoglobulin G Fc glycosylation
Part III: Effector Functions & Diseases
Sweet rules
linking glycosylation to antibody function
Immunoglobulin G glycosylation in diseases
Immunoglobulin A glycosylation and its role in diseases
Part IV: Applications
Importance and monitoring of therapeutic immunoglobulin G glycosylation
Glycosylation of plant-produced immunoglobulins
The rapidly expanding nexus of immunoglobulin G N-glycomics, suboptimal health status, and precision medicine
Glycosylation of antigen-specific antibodies
Perspectives on immunoglobulin G glycosylation in vaccination and immunotherapy.

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