Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.
Zhang, Yunjiao, author.
2022
TA418.9.N35 Z53 2022
Available Online

Linked e-resources

Linked Resource
Online Access
Concurrent users
Unlimited
Authorized users
Authorized users
Document Delivery Supplied
Can lend chapters, not whole ebooks

Details

Title
Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.
Author
Zhang, Yunjiao, author.
ISBN
9789811681660 (electronic bk.)
981168166X (electronic bk.)
9789811681653
9811681651
DOI
https://doi.org/10.1007/978-981-16-8166-0
Published
Singapore : Springer, [2022]
Copyright
©2022
Language
English
Description
1 online resource (xv, 156 pages) : illustrations (chiefly color).
Item Number
10.1007/978-981-16-8166-0 doi
Call Number
TA418.9.N35 Z53 2022
Dewey Decimal Classification
620.1/15
Summary
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Note
"Doctoral thesis accepted by University of Science and Technology of China, Hefei, China."
Access Note
Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed January 10, 2022).
Series
Springer theses. 2190-5061
Available in Other Form
Print version: 9789811681653
Linked Resources
Online Access
Record Appears in
Online Resources > Ebooks
All Resources
Introduction
Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials
RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN)
Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating
RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo
Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.

Browse Subjects

Show more subjects...

Statistics

from
to
Export