Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.
2022
TA418.9.N35 Z53 2022
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Title
Tuning autophagy-inducing activity and toxicity for lanthanide nanocrystals / Yunjiao Zhang.
Author
Zhang, Yunjiao, author.
ISBN
9789811681660 (electronic bk.)
981168166X (electronic bk.)
9789811681653
9811681651
981168166X (electronic bk.)
9789811681653
9811681651
Published
Singapore : Springer, [2022]
Copyright
©2022
Language
English
Description
1 online resource (xv, 156 pages) : illustrations (chiefly color).
Item Number
10.1007/978-981-16-8166-0 doi
Call Number
TA418.9.N35 Z53 2022
Dewey Decimal Classification
620.1/15
Summary
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Note
"Doctoral thesis accepted by University of Science and Technology of China, Hefei, China."
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Access limited to authorized users.
Digital File Characteristics
text file PDF
Source of Description
Online resource; title from PDF title page (SpringerLink, viewed January 10, 2022).
Series
Springer theses. 2190-5061
Available in Other Form
Print version: 9789811681653
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Table of Contents
Introduction
Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials
RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN)
Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating
RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo
Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.
Phage display identifies a specific high-affinity binding peptide RE-1 for lanthanide (LN) nanomaterials
RE-1 forms a stable coating layer on the surface of upconversion nanoparticles / nanocrystals (UCN)
Reduction of UCN sedimentation and nanomaterial-cell interaction by RE-1 coating
RE-1 coating abrogates autophagy induction and toxicity for UCN in vitro and in vivo
Enhancement of cell interaction and autophagy induction by coating with RE-1-RGD.-Conclusion and prospect.