Toll-Like receptors in health and disease / Vijay Kumar, editor.
Kumar, Vijay (Expert in medical bacteriology and immunology)
2022
QH603.C43
Available Online

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Title Toll-Like receptors in health and disease / Vijay Kumar, editor.
ISBN 9783031065125 (electronic bk.)
3031065123 (electronic bk.)
3031065115
9783031065118
DOI https://doi.org/10.1007/978-3-031-06512-5
Publication Details Cham : Springer, 2022.
Language English
Description 1 online resource (316 pages)
Item Number 10.1007/978-3-031-06512-5 doi
Call Number QH603.C43
Dewey Decimal Classification 616.079
Summary The current book is focussed on the Toll-like receptors (TLRs), which are the first pattern recognition receptors (PRRs) discovered in humans. For example, TLR4 was first recognized in humans in 1997 as a PRR recognizing the Gram-negative bacterial lipopolysaccharide (LPS). This discovery revolutionized the field of innate immunity and filled the long-standing gap in the pathogen recognition by the immune system. Now, it is well established that humans have 10 (TLR1-TLR10) and mice have 12 (TLR1-TLR13) functional TLRs, excluding TLR10 that is present as a defective pseudogene. TLRs are present as both membrane-bound extracellular (TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10) and intracellular (TLR3, TLR7, TLR8, and TLR9) PRRs in humans, which identify different pathogen or microbe-associated molecular patterns (PAMPs or MAMPs) and death or damage-associated molecular patterns (DAMPs) released by the host cells. A lot of development in the TLR biology has occurred in last 24 years since there first discovery in humans. The book is intended to describe their role in the host defence, human reproduction, non-infectious sterile inflammatory conditions, including brain immunity and cerebrovascular diseases, signaling mechanisms, adaptive immunity, and their targeting for drug development.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed June 16, 2022).
Added Author Kumar, Vijay (Expert in medical bacteriology and immunology)
Series Handbook of experimental pharmacology ; v. 276.
Available in Other Form Toll-Like Receptors in Health and Disease.
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
All Resources
Intracellular TLRs (TLR3, TLR7, and TRL9) in host defense or TLRs in mast cells
Toll-like receptors as drug targets in the intestinal epithelium
Innate immune memory-priming, tolerance and exhaustion-in health and disease
TLRs in brain immunity
TLRs in cerebrovascular diseases
TLRs in stem cells or progenitor cells
TLRs in adaptive immunity
Overview on TLRs in immunity
TLR10 and its role in immunity.

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