Intro
Preface
Contents
About the Editors
Chapter 1: Introduction: Progression of the Science of Ageing
Introduction
References
Chapter 2: Chromatin Structure from Development to Ageing
Introduction
Nuclear Architecture
The Nuclear Envelope
Nuclear Lamina
Chromosome Territories
Chromatin 3D Organization and Dynamics
Compartments
Topologically Associated Domains (TADs)
Lamina-Associated Domains (LADs)
Chromatin Restructuring During Development
DNA Methylation
Histone Variants
Histone Modifications
Nuclear Remodeling in Development

Lamins Regulate Nuclear Structure and Chromatin Organization During Development
Programmed Cellular Senescence
Chromatin Remodeling in Ageing
Persistent Cellular Senescence
Changes in Chromatin Structure and Histone Variants in Cellular Senescence
DNA Methylation
Histone Variants and Modifications
Nuclear and 3D Genome Remodeling in Ageing
The Role of Lamins in Regulating Chromatin Organization During Ageing
Concluding Remarks
References
Chapter 3: The Nuclear Envelope in Ageing and Progeria
Introduction

The Nuclear Lamina in Ageing and Premature Ageing Syndromes
Nuclear Pore Complex Turnover and Decline in Ageing
The Implication of Nucleocytoplasmic Transport in Neurodegenerative Disease
RNA-Binding Proteins and Neurodegenerative Diseases
Peptide Repeat Toxicity and NPC Function
Additional Implications of NCT in Neurodegenerative Diseases
Concluding Remarks
References
Chapter 4: Mitochondrial DNA Mutations and Ageing
Introduction
Mitochondrial Structure and Function
Oxidative Phosphorylation
Mitochondrial Genetics
Mitochondrial DNA Mutations in Ageing

MtDNA Deletions
MtDNA Point Mutations
Mouse Models of Mitochondrial Alterations with Ageing
Mitochondrial Function and Stem Cell Ageing
MtDNA Mutations and Stem Cell Ageing
Mitochondrial Regulation of the Ageing Immune System
Targeting Mitochondria in Ageing
Concluding Remarks
References
5: The Proteasome and Ageing
Introduction
The Proteasome: A Brief Overview
Cellular Senescence and the Proteasome
Muscle Ageing and the Proteasome
Skin Ageing and the Proteasome
Brain Ageing and the Proteasome
Proteasome and Age-Related Neurodegenerative Diseases

Proteasome and Longevity
Other Components of the Ubiquitin-Proteasome Pathway Implicated in Ageing
Activating the Proteasome to Decelerate the Ageing Process
Conclusion and Future Directions
References
6: Gap Junctions and Ageing
Introduction
Gap Junctions and the Connexin Family
Regulation of Gap Junctions at the Molecular Level
Gene Structure and Transcription
Translation
Trafficking
Posttranslational Modification of Connexins
Heart
Brain
The Ocular System
Bone
Other Tissues
Concluding Remarks
References