Intro
Preface
Contents
Contributors
Part I: Rethinking and Paradigm Shift
1: Neuron-Microglia Crosstalk in Neuropsychiatric Disorders
1.1 Introduction
1.2 Physiological Roles of Microglia
1.3 Neuron-Microglia Crosstalk in Depression
1.4 Neuron-Microglia Crosstalk in Schizophrenia
1.5 Neuron-Microglia Crosstalk in Neurocognitive Disorder
1.6 Conclusions
References
2: Microbiota-Gut-Brain Axis: Pathophysiological Mechanism in Neuropsychiatric Disorders
2.1 Introduction
2.2 Microbiota-Gut-Brain Axis

2.3 Potential Communication Pathways Between Gut Microbiota and the Brain
2.3.1 Immunological Pathway
2.3.2 Microbial Metabolites
2.3.3 Endocrine System
2.3.4 Autonomic Nervous System
2.4 The Role of Gut-Microbiota-Brain Axis in Neuropsychiatric Illnesses
2.4.1 Autism Spectrum Disorder
2.4.2 Schizophrenia
2.4.3 Depression
2.4.4 Alzheimerś Disease
2.4.5 Parkinsonś Disease
2.5 Modulation of Gut Microbiota for the Treatment of Neuropsychiatric Disorders
2.6 Conclusions
References

3: Inflammation-Mediated Responses in the Development of Neurodegenerative Diseases
3.1 Introduction
3.2 Hallmarks of Neurodegenerative Diseases
3.3 The Role of Inflammation in the Development of Neurodegeneration
3.4 The Role of Neuroinflammation in the Pathogenesis of Neurodegenerative Diseases
3.4.1 Alzheimerś Disease
3.4.2 Parkinsonś Disease
3.4.3 Amyotrophic Lateral Sclerosis
3.4.4 Multiple Sclerosis
3.5 Model Systems Available to Study Inflammatory-Mediated Neurodegenerative Diseases
3.5.1 Alzheimerś Disease
3.5.2 Parkinsonś Disease

3.5.3 Amyotrophic Lateral Sclerosis
3.6 Concluding Remarks and Future Directions
References
4: Microbiome-Induced Autoimmunity and Novel Therapeutic Intervention
4.1 Introduction
4.2 Microbiome-Induced Autoimmunity
4.2.1 Microbiome
4.2.2 Maternal Microbiota
4.2.3 Hygiene Hypothesis
4.2.4 Epithelial Barrier Hypothesis and Leaky Gut Syndrome (LGS)
4.2.5 Dysbiosis
4.2.6 The Role of B Cells
4.2.7 The Role of Toll-like Receptor (TLR) Ligands
4.2.8 Autoimmunity
4.3 Novel Therapeutic Intervention
4.3.1 Engineering the Gut Microbiota

4.3.2 Personalized Nutrition
4.3.3 Probiotics and Prebiotics
4.3.4 Fecal Microbiota Transplantation (FMT)
4.3.5 Vaccination
4.4 Conclusion
References
5: Animal Inflammation-Based Models of Neuropsychiatric Disorders
5.1 Introduction
5.2 Animal Models of Inflammation and CNS Disorders
5.3 Zebrafish Models
5.4 Conclusion
References
6: Early Life Stress, Neuroinflammation, and Psychiatric Illness of Adulthood
6.1 Introduction
6.2 Early Life Stress and Inflammation
6.2.1 Experimental Animal Studies
6.3 Early Life Stress and Inflammation