Intro
Preface
Contents
Part I: Basic Science of Lung Cancer
Genomic Alterations in Lung Cancer
1 Introduction
2 NSCLC
3 EGFR
4 ALK
5 ROS1
6 BRAF
7 MET
8 RET
9 NTRK
10 HER2
11 KRAS
12 FGFR
13 Small Cell Lung Cancer
14 Conclusion
References
Epigenetic Events in Lung Cancer
1 Introduction
2 Classification of the Epigenetic Modifications
2.1 DNA Methylation
2.2 Regulators of the Chromatin Structure: Histone Modifiers
2.2.1 Histone Acetyltransferases
2.2.2 Histone Deacetylases

2.2.3 Histone Methyltransferases
2.2.4 Histone Demethylases
2.3 Regulators of the Chromatin Structure: Chromatin Remodeling Complexes
3 Landscape of the Epigenetic Abnormalities in Lung Cancer
3.1 Aberrant DNA Methylation
3.2 Gene Abnormalities Affecting Chromatin Remodelers: The SWI/SNF Complex
3.3 Abnormalities in Histone Modifiers
4 Epigenetic-Based Therapeutic Strategies in Lung Cancer
4.1 DNA Methyltransferase Inhibitors
4.2 Histone Deacetylase Inhibitors
4.3 Other Epigenetic Inhibitors
5 Conclusions and Future Directions
References

Part II: Clinical Investigations
Interventional Pulmonology
1 Introduction
2 Diagnostic Techniques
2.1 Autofluorescence Videobronchoscopy
2.2 Narrow-Band Imaging
2.3 Endobronchial Ultrasound
2.4 Recent Diagnostic Techniques in Interventional Pulmonology
3 Therapeutic Techniques
3.1 Techniques with Immediate Effect
3.1.1 Nd:YAG and Ho:YAG Laser Photoresection
3.1.2 Electrocautery
3.1.3 Argon Plasma Coagulation
3.2 Techniques with Delayed Effect
References
Pathology of Lung Cancer
1 Introduction
2 Adenocarcinoma
2.1 Background

2.2 Major Adenocarcinoma Patterns
2.3 Adenocarcinoma Variants
2.4 Nonmucinous Adenocarcinoma Classification
2.5 Grading of Lung Adenocarcinoma
2.6 Staging Issues Associated with Adenocarcinoma
3 Squamous Cell Carcinoma
3.1 Background
3.2 Histology of Squamous Cell Carcinoma
3.3 Differentiation of Primary Squamous Cell Carcinoma of the Lung from Metastatic Squamous Cell Carcinoma
4 Adenosquamous Carcinoma
5 Pleomorphic Carcinoma
6 Neuroendocrine Neoplasms of the Lung
6.1 Background
6.2 Histology of Neuroendocrine Neoplasms

6.3 Immunohistochemistry for Neuroendocrine Neoplasms
6.4 Ki-67 Proliferative Index for Pulmonary Neuroendocrine Neoplasms
7 Molecular Diagnostics in NSCLC and Triage of Limited Tissue Samples for Comprehensive Diagnosis
8 Pathology Assessment of Post-Neoadjuvant Resections for NSCLC
References
Role of Radiologic Imaging in Lung Cancer
1 Introduction, Technical Advances
2 Diagnosis of Lung Cancer/Solitary Pulmonary Nodule
3 T Staging/NSCLC
4 N Staging/NSCLC
5 M Staging/NSCLC
6 CT in Treatment Response Assessment and Follow-Up of NSCLC
References