Environmental oncology : theory and impact / editor, Eric H. Bernicker.
Bernicker, Eric H.
2023
RC268.25
Available Online

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Title Environmental oncology : theory and impact / editor, Eric H. Bernicker.
ISBN 9783031337505 (electronic bk.)
3031337506 (electronic bk.)
3031337492
9783031337499
DOI https://doi.org/10.1007/978-3-031-33750-5
Published Cham : Springer, 2023.
Language English
Description 1 online resource.
Other Standard Identifiers 10.1007/978-3-031-33750-5 doi
Call Number RC268.25
Dewey Decimal Classification 616.994
Summary This book covers the wide range of malignant illness and where they intersect with environmental factors. Chapters explore the importance of acknowledging and dealing with the societal implications of anthropogenic climate change, a wider appreciation of the many ways that human industry and activity is changing the environment and contributing to human disease is imperative. In addition to how particular exposures relate to certain malignancies, the book explores historical events that led to the development of cancers in order to help policy makers and patient advocates understand where we have been when considering future initiatives. It also discusses the disparities involved in environmental toxin exposure and look at these cancers in light of the need to reduce cancer disparities. Given the ongoing ecological crisis from climate change and expanding human population and industrialization, this book examines pollution and ecological change to impacts and where human disease can be prevented.
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed September 14, 2023).
Added Author Bernicker, Eric H.
Available in Other Form Environmental Oncology
Linked Resources Online Access
Record Appears in Online Resources > Ebooks
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1: Molecular Mechanisms of Environmental Oncogenesis
Overview
Cancer Etiology
Genetic Causes of Cancer
Environmental Causes of Cancer
Lifestyle and Cancer
Smoking
Alcohol
Diet
Obesity
Physical Activity
Infectious Agents
Environmental and Lifestyle Influences by Cancer Type
Concluding Remarks
References
2: Air Pollution and Cancer
Sources of Air Pollution
Biology of Interaction Between Particles and the Respiratory Epithelium
Respiratory Epithelium
Barrier Dysfunction
Mucociliary Dysfunction

Immune-Mediated Alterations in Airway Epithelial Barrier Function upon Exposure to Air Pollutants
Alveolar Macrophages
Air Pollution and Cancer Development
Air Pollution as Complicating Factor in Establish Cancer patient's Care
Air Pollution and Other Non-cancerous Illnesses
Summary and Call to Action
References
3: Leaving No Stone Unturned: Unraveling the Path to Maximizing the Potential for Discovery of Novel Antineoplastics
Introduction
Vinca Alkaloids
Discovery and Origin
Pharmacology
Vinblastine
Vincristine
Vinorelbine
Clinical Use
Taxanes

Discovery and Origin
Pharmacology
Paclitaxel
Docetaxel
Cabazitaxel
Clinical Use and Impact
Camptothecin Derivatives
Discovery and Origin
Pharmacology
Topotecan
Irinotecan
Clinical Use and Impact
Epipodophyllotoxins
Discovery and Origin
Pharmacology
Etoposide
Teniposide
Clinical Use and Impact
Potential Impact of Deforestation on Cancer Drug Discovery
References
Part II: Food, Lifestyle and Cancer
4: Meat and Alcohol Consumption: Diet and Lifestyle Choice and Cancer
Introduction
Meat Consumption and Cost

The Role of Heme Iron in Colon Cancer
Gut Microbiome and Colon Cancer
Immunotherapy and Colorectal Cancer
Societal Costs and Colorectal Cancer
Alcohol Intake and Cancer Risk
Alcohol and Breast Cancer
Alcohol and Head and Neck Cancer
Alcohol and Upper and Lower GI Cancer
Conclusion
References
5: Tobacco, Second-Hand Smoke and Cancer
Introduction
Tobacco Smoking and Second-Hand Smoke
Smoke-Induced Oxidative Stress in the Pathogenesis of COPD
Oxidative Stress-Induced Damage in COPD
Mitochondrial Dysfunction in COPD
Inflammation in COPD

The Relationship Between COPD and Lung Cancer
Oxidative Stress-Induced DNA Damage Links COPD to Lung Cancer
Mitochondrial Dysfunction Links COPD to Lung Cancer
Inflammation Links COPD to Lung Cancer
Epigenetics Link COPD to Lung Cancer
Smoking and the Management of Cancer
Conclusions
References
6: Sun Exposure and Skin Cancer
Foreword
Brief History and Evidence for Climate Change
Complex Mechanisms of the Earth System Model
How Climate Change Is Studied
Climate Change Predictions and Models for the Current Century
The Mechanism of UV Radiation-Related Cutaneous Carcinogenesis

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