Sex and gender differences in infection and treatments for infectious diseases / Sabra L. Klein, Craig W. Roberts, editors.
Klein, Sabra L.; Roberts, Craig W.
2023
RC112
Available Online

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Title Sex and gender differences in infection and treatments for infectious diseases / Sabra L. Klein, Craig W. Roberts, editors.
Edition 2nd ed.
ISBN 9783031351396 (electronic bk.)
3031351398 (electronic bk.)
303135138X
9783031351389
DOI https://doi.org/10.1007/978-3-031-35139-6
Imprint Cham : Springer, 2023.
Language English
Description 1 online resource (281 p.).
Other Standard Identifiers 10.1007/978-3-031-35139-6 doi
Call Number RC112
Dewey Decimal Classification 616.9
Summary This fully revised and significantly expanded second edition examines sex and gender differences in the immune system's response to bacterial, viral, and parasitic infections. The volume discusses both common and distinct molecular mechanisms that mediate these differences and illustrates how responses to vaccines may differ between the sexes and in pregnant individuals. Special emphasis is placed on the interplay between hormones and the immune system in the pathogenesis of HIV, SARS-CoV-2, influenza, malaria, tuberculosis, and amebiasis. This second edition includes completely rewritten chapters as well as all new contents. This book is intended for researchers in academia and industry as well as clinicians in the fields of microbiology, immunology, and pharmacology. By expanding knowledge in sex and gender medicine as a basis for developing personalized treatment strategies, the book contributes to UN Sustainable Development Goals 3 (health and well-being) and 5 (gender equality).
Note 2.4 Animal Models of Sex Differences in Influenza Pathogenesis
Bibliography, etc. Note Bibliography -- The Influence of Sex Hormones and X Chromosome in Immune Responses -- 1 Introduction -- 2 Sex Hormone Signaling and X Chromosome Dosage Effects -- 2.1 Sex Steroid Hormones Signaling -- 2.2 X Chromosome Gene Dosage and X Chromosome Inactivation Escape -- 3 Biological Role of Sex-Linked Factors in Autoimmunity -- 3.1 Sex Hormone and X Chromosome Regulation in Organ-Specific Autoimmunity: The Example of Multiple Sclerosis. -- 3.2 Sex Hormones and X Chromosome Effects in Systemic Autoimmunity (SLE)
Access Note Access limited to authorized users.
Source of Description Online resource; title from PDF title page (SpringerLink, viewed September 25, 2023).
Added Author Klein, Sabra L.
Roberts, Craig W.
Series Current topics in microbiology and immunology ; v. 441.
Available in Other Form Sex and Gender Differences in Infection and Treatments for Infectious Diseases
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Intro
Contents
Genetics of Sex Differences in Immunity
1 Evolutionary Perspective
2 Sex Chromosomes
2.1 X Chromosome Inactivation
2.2 Immune-Related Genes on the Sex Chromosomes
2.3 Sex Chromosome Abnormalities and the Immune System
3 Experimental Models for Studying the Sex Effect on Immunity
3.1 Four Core Genotypes Mouse Model
3.2 Human Cell Lines with Sex Chromosome Aberrations
3.3 Additional Mouse Models
4 Female-Specific States and Their Immune Consequences
4.1 Pregnancy as a Graft
4.2 Microchimerism in Fetal Cells
5 Concluding Remarks

4 Sex Differences in Allergic Asthma: A Prominent Role of Sex Steroid Hormone Signaling
4.1 Sex Bias in Asthma Prevalence and Severity
4.2 Impact of Sex Hormones in Type 2 Mediated Allergic Airway Inflammation
5 Biological Sex Influences Natural Immunity to Neonatal Pathogens and Cancer
5.1 Sex-Biased Dimorphism in Bloodstream Infections: The Role of Estrogens/Peritoneal Macrophages/B-1 Cells Axis
5.2 Sex Dimorphism in Solid Tumor Control: From Innate to Acquired Immunity
References
Sex Differences in HIV Infection
1 Introduction
2 Sex Differences in HIV Acquisition

3 Sex Differences in HIV Pathogenesis
4 Immune Mechanisms Underlying Sex Differences
5 Sex Differences in ART-Treated Disease
6 Summary
References
Effects of Biological Sex and Pregnancy on SARS-CoV-2 Pathogenesis and Vaccine Outcomes
1 Sex Differences in Viral Pathogenesis
2 Sex Differences in SARS-CoV-2 Pathogenesis
2.1 SARS-CoV-2 Entry, Replication, and Transmission
2.2 Development of Innate and Adaptive Immune Responses
2.3 Sex Differences in Post-Acute Sequelae SARS-CoV-2 Infection (PASC)
2.4 Comorbidities, Sex Difference, and COVID-19

2.5 Role of Sex Steroids
2.6 Role of Genetic Variations
3 Pregnancy and SARS-CoV-2 Pathogenesis
4 Sex Differences in COVID-19 Vaccine Outcomes
4.1 Immunogenicity
4.2 Effectiveness
4.3 Vaccine Reactogenicity
5 Pregnancy and COVID-19 Vaccines
6 Conclusions and Future Directions
References
Biological Sex and Pregnancy Affect Influenza Pathogenesis and Vaccination
1 Introduction
2 Sex Differences in Influenza Pathogenesis
2.1 Seasonal Influenza Epidemics
2.2 Outbreaks of Avian Influenza
2.3 Influenza A Virus Pandemics

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