Purinergic receptors and their modulators / Vittoria Colotta, Claudiu T. Supuran, editors.
Colotta, Vittoria, editor.; Supuran, Claudiu T., 1962- editor.
2023
QP801.P8
Available Online

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Title Purinergic receptors and their modulators / Vittoria Colotta, Claudiu T. Supuran, editors.
ISBN 9783031397257 (electronic bk.)
3031397258 (electronic bk.)
303139724X
9783031397240
DOI https://doi.org/10.1007/978-3-031-39725-7
Published Cham, Switzerland : Springer, 2023.
Language English
Description 1 online resource (240 pages).
Other Standard Identifiers 10.1007/978-3-031-39725-7 doi
Call Number QP801.P8
Dewey Decimal Classification 547/.596
Summary This book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the synthesis, properties, and functional potential of adenosine receptor ligands, probes, and functional conjugates. In the next chapters, experts in the field delve into topics such as the therapeutic potential of adenosine receptor ligands in wound healing and fibrosis, the therapeutic benefits of A2A receptor antagonists, the A2B adenosine receptor as a target for brain ischemia or demyelination, the development and latest advancements in clinical trials of A3 adenosine receptor ligands. Other chapters describe bifunctional tools to study adenosine receptors, allosteric modulators of adenosine receptors, and new computational approaches to inspect adenosine receptor-ligand recognition processes. Furthermore, the book discusses the role of P2X4 receptors in immunity and inflammation. The final chapters illustrate CD73 inhibitors as antitumor agents, and bacterial ectonucleotidases as underexplored antibacterial drug targets. This book is a valuable resource for scholars working in the field of medicinal chemistry, as well as researchers in the industry, providing readers with a comprehensive understanding of adenosine receptor biology and its therapeutic potential.
Access Note Access limited to authorized users.
Source of Description Description based on print version record.
Added Author Colotta, Vittoria, editor.
Supuran, Claudiu T., 1962- editor.
Series Topics in medicinal chemistry (Springer (Firm)) ; v. 41.
Available in Other Form PURINERGIC RECEPTORS AND THEIR MODULATORS.
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All Resources
Once upon a time adenosine and its receptors. Historical survey and perspectives as potential targets for therapy in human diseases
Adenosine receptor ligands, probes and functional conjugates: A twenty-year history of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines (PTP)
Adenosine receptor ligands as potential therapeutic agents for impaired wound healing and fibrosis
Adenosine A2A receptor antagonists: chemistry, SARs, modeling studies and therapeutic potential
A2B Adenosine Receptor as a new and attractive target to treat brain ischemia or demyelination
A3 adenosine receptor ligands: from discovery to clinical trials
Bifunctional tools to study adenosine receptors
Allosteric modulators of adenosine receptors
New computational approaches in inspecting adenosine receptor-ligand recognition process
P2X4 receptors in immunity and inflammation
CD73 inhibitors as antitumor agents
Bacterial ectonucleotidases- underexplored antibacterial targets.

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