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Intro
Acknowledgment
Contents
Abbreviations
About the Author
List of Figures
Contents
1 Introduction
1.1 Introduction to the Second Edition, 2024
1.2 Introduction to First Edition
References
2 Classes and Applications of Cell-Penetrating Peptides
Abstract
2.1 Protein Derived Versus Designed
2.2 Classification by Physico-Chemical Properties Versus Structural Properties
2.3 Predicted Versus Random
2.4 Linear Versus Modified
2.4.1 Linear
2.4.2 Stabilized
2.5 Protein Mimics Versus Cargo Delivery Vectors
2.5.1 Protein-Mimicking CPPs

2.5.2 CPPs for Cargo Delivery
2.6 Nonspecific Versus Targeted
2.6.1 Affinity Targeting: Homing, Ligand Based Targeting
2.6.2 Prodrug Approach, aCPP
2.7 Classification by Uptake Mechanisms
2.7.1 Direct Translocators
2.7.2 Endocytosis Enhancers
2.8 Non-toxic Versus Antimicrobial
2.8.1 Non-toxic
2.8.2 Antimicrobial
References
3 Methods for CPP Selection, Prediction and in Silico Analysis
Abstract
3.1 Selection
3.2 Prediction
3.3 Cargo Delivery Vectors
References
4 Labeling of CPPs
Abstract
4.1 Radioactive CPP Labelling

4.2 Fluorescent Labelling of CPPs
4.3 Quantum Dots
4.4 Fluorescence Quenching
4.5 Luciferin-CPP Conjugates
References
5 Methods for CPP Functionalization with Oligonucleotides
Abstract
5.1 Antisense
5.1.1 Antisense Delivery
5.1.2 Splicing Redirection Assay
5.1.3 MicroRNAs and Anti-MicroRNAs
5.1.4 Decoy Oligonucleotides
5.1.5 Live Cell Genomics
5.2 siRNA Delivery Methods
References
6 Additional Gene Therapeutic Platforms
Abstract
6.1 Plasmid Delivery
6.2 Cellular Reprogramming
6.3 Genome Editing
References

7 Protein Delivery and Mimicry
Abstract
7.1 Fusion Proteins
7.2 Chemical Conjugation of CPPs to Proteins
7.3 Biotin Conjugations
7.4 Complexation of Proteins and Peptides
7.5 Targeting Proteins with CPPs
7.6 Protein Mimicry and PPI
7.6.1 Delivery of Protein Mimics as Cargos by CPPs
7.6.2 Protein Mimics with CPP Properties
References
8 General Targeting Strategies
Abstract
8.1 "Addressing"
8.2 Prodrug Strategies
References
9 Targeting Specific Barriers
Abstract
9.1 Targeting Intracellular Organelles with CPPs

9.1.1 Nuclear and Nucleolar Targeting
9.1.2 Lysosomal Targeting
9.1.3 Mitochondrial Targeting
9.1.4 Golgi and Endoplasmic Reticulum Targeting
9.2 Targeting Biological Tissue Barriers
9.2.1 Oral Administration
9.2.2 Inhalation Delivery
9.2.3 Intranasal Delivery
9.2.4 Transdermal Delivery
9.2.5 Delivery Across Blood-brain-Barrier, BBB
9.3 Targeting Plants
References
10 Methods for Molecular Imaging, Detection and Visualization of CPPs
Abstract
10.1 HPLC Analysis
10.2 Mass-Spectrometric Methods
10.3 Radionuclide Imaging
10.4 Optical Imaging

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