Intro
Preface
Acknowledgments
Contents
1 Introduction
References
2 Drug Conjugation Chemistry in Iron Oxide Nanoparticles (IONPs)
2.1 Covalent Drug-Conjugated Iron Oxide Nanoparticles
2.1.1 Amide Linkage Drug Conjugation
2.1.2 Drug Conjugation with pH-Sensitive Bonding
2.1.3 Drug Conjugation with Enzymatically Responsive Bonding
2.1.4 Oxidation/Reduction Drug Conjugation
2.2 Non-Covalent Drug-Conjugated Iron Oxide Nanoparticles (IONPs)
2.2.1 Hydrophobic Drug Conjugation
2.2.2 Drug Conjugation Using Electrostatics

2.2.3 Drug Conjugation with Encapsulation
References
3 Superparamagnetic Iron Oxide Nanoparticle (SPION) Synthesis
3.1 Physical Methods
3.1.1 Deposition in the Gas Phase
3.1.2 Lithography Using Electronic Beam
3.1.3 Laser Ablation with Pulses
3.1.4 Pyrolysis Caused by a Laser
3.1.5 Strong Ball Milling
3.1.6 Combustion
3.2 Chemical Methods
3.2.1 Chemical Coprecipitation Synthesis
3.2.2 Thermolysis (Thermal Decomposition)
3.2.3 Microemulsions
3.2.4 Synthesis Using Hydrothermal Method
3.3 Biological Approach
References

4 Properties of Iron Oxide Nanoparticles (IONPs)
4.1 Structural Properties
4.1.1 Colloidal Stability
4.1.2 Shape and Size
4.1.3 Charge of Surface
4.2 Magnetic Properties
4.3 Thermal Properties
4.4 Optical Properties
4.4.1 Fluorescence Techniques and Encapsulated IONPs
References
5 Pharmacokinetics of IONPs
5.1 Absorption/Uptake
5.1.1 Size and Coating Material's Impact on Absorption
5.1.2 Charge's Impact on Uptake and Absorption
5.1.3 Uptake of IONPs in the Brain
5.2 Distribution

5.2.1 Iron and IONP Physicochemical Properties Affecting the Distribution
5.3 Metabolism
5.4 Affecting the Cell Physiology
5.4.1 Influence on Cell Proliferation
5.4.2 Effect on Stem Cell Differentiation
5.4.3 Affects Cell Migration
5.5 Excretion
5.6 Regulation of Iron in Human
5.6.1 Human Body's Iron Flow
5.6.2 The Liver Is the Main Organ for Iron Homeostasis
5.6.3 Iron Regulation
5.6.4 Macrophages Are in Charge of Iron Homeostasis
5.6.5 Monocytes and the Iron Metabolism Process
5.6.6 Iron-Related Infection and Immunity
References

6 Magnetic Nanoparticles in Stimuli-Responsive Drug Delivery Systems
6.1 Drug Delivery Systems with Stimuli-Responsiveness Through Ligand-Mediated MNPs
6.1.1 Organic Ligands
6.1.2 Inorganic Ligands
6.1.3 Hybrid Inorganic-Organic Ligands
6.2 The Most Common Methods for Synthesizing MNP-Based Drug Delivery Systems
6.2.1 Thin Films Hydration
6.2.2 Evaporation Emulsion
6.2.3 Solvent Exchange
References
7 IONPs-Based Treatment Methods
7.1 Chemotherapy
7.2 Stimuli-Responsive Delivery Nanoplatforms
7.2.1 Endogenous Stimuli-Responsive Nanoplatforms