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Table of Contents
Intro
About the Authors
Acknowledgements
Contents
Foreword
Preface
Introduction: The Marathon of the Messenger RNA...
Part I Messenger RNA, An Essential Role and Challenge
1 A Short History of Vaccination
References
2 From DNA to RNA
2.1 The Skeleton of DNA and RNA
References
3 Messenger RNA (mRNA): From Transcription to Protein Translation
4 The Mechanism of Viral Infection
4.1 The AIDS Virus and New Viruses
5 The Immune Response
5.1 The Role of Cytokines
5.2 Facilitating Antibodies
References
Part II From Preliminary Studies to Clinical Trials
6 Promising Studies in the 1990s
References
7 The Use of mRNA-The Initial Technical Obstacles
References
8 The Birth of CureVac: The Era of the Pioneers
References
9 Solutions for mRNA Optimization
References
10 Modified and Unmodified mRNA: For What Purpose?
References
11 Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA
References
12 Experiments and Clinical Trials Against Infectious Diseases
12.1 The Role of Type 1 Interferon in Triggering the Adaptive Immune Response
18 The Importance of Intellectual Property and Patents
References
19 2020: The Triumph of Anti-Covid mRNA Vaccines
19.1 Additional Data on Anti-Covid mRNA Vaccines
References
20 mRNA, a Technology of the Future
References
Conclusion
Postfaces
Afterword by Chantal Pichon
Afterword by Steve Pascolo
Glossary
About the Authors
Acknowledgements
Contents
Foreword
Preface
Introduction: The Marathon of the Messenger RNA...
Part I Messenger RNA, An Essential Role and Challenge
1 A Short History of Vaccination
References
2 From DNA to RNA
2.1 The Skeleton of DNA and RNA
References
3 Messenger RNA (mRNA): From Transcription to Protein Translation
4 The Mechanism of Viral Infection
4.1 The AIDS Virus and New Viruses
5 The Immune Response
5.1 The Role of Cytokines
5.2 Facilitating Antibodies
References
Part II From Preliminary Studies to Clinical Trials
6 Promising Studies in the 1990s
References
7 The Use of mRNA-The Initial Technical Obstacles
References
8 The Birth of CureVac: The Era of the Pioneers
References
9 Solutions for mRNA Optimization
References
10 Modified and Unmodified mRNA: For What Purpose?
References
11 Experiments and Clinical Trials Conducted: The Power of Therapeutic mRNA
References
12 Experiments and Clinical Trials Against Infectious Diseases
12.1 The Role of Type 1 Interferon in Triggering the Adaptive Immune Response
18 The Importance of Intellectual Property and Patents
References
19 2020: The Triumph of Anti-Covid mRNA Vaccines
19.1 Additional Data on Anti-Covid mRNA Vaccines
References
20 mRNA, a Technology of the Future
References
Conclusion
Postfaces
Afterword by Chantal Pichon
Afterword by Steve Pascolo
Glossary