The importance of cardiac safety assessments
The biological basis of adverse drug reactions
Cardiac structure and function
Cardiac pathophysiology and disease
Drug discovery and drug design
Nonclinical development
The thorough QT/QTc trial
General safety assessments
Therapeutic use trials and meta-analyses
Assessment methodologies in nonexperimental postmarketing surveillance
Postmarketing proarrhythmic cardiac safety assessments
Generalized cardiac safety
Medication errors, adherence, and concordance
Future directions in drug safety.