Physiologically-based pharmacokinetic (PBPK) modeling and simulations [electronic resource] : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters.
Peters, Sheila Annie.
2011
RM301.5 .P48 2011eb
Available Online

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Title Physiologically-based pharmacokinetic (PBPK) modeling and simulations [electronic resource] : principles, methods, and applications in the pharmaceutical industry / Sheila Annie Peters.
Author Peters, Sheila Annie.
ISBN 9780470484067 (cloth)
9781118140383 (e-book)
Publication Details Hoboken, N.J. : Wiley, c2011.
Language English
Description xvii, 430 p. : ill.
Call Number RM301.5 .P48 2011eb
Dewey Decimal Classification 615/.7
Bibliography, etc. Note Includes bibliographical references and index.
Access Note Access limited to authorized users.
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Record Appears in Online Resources > Ebooks
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Modelling in the pharmaceutical industry
Physiologically-based modelling
A review of pharmacokinetic principles
Physiological model for absorption
Physiological model for distribution
Physiological models for drug metabolism and excretion
Generic whole-body physiologically-based pharmacokinetic modelling
Variability, uncertainty and sensitivity analysis
Evaluation of drug-drug interaction risk with pbpk models
PBPK of biotherapeutics
Data integration and sensitivity analysis
Hypothesis generation and pharmacokinetic predictions
Integration of PBPK and pharmacodynamics
PBPK modelling of populations
PBPK models along the drug discovery and development value chain.

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